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Titolo:
The use of Gd-DTPA as a marker of myocardial viability in reperfused acutemyocardial infarction
Autore:
Pereira, RS; Prato, FS; Wisenberg, G; Sykes, J; Yvorchuk, KJ;
Indirizzi:
Univ Western Ontario, St Josephs Hlth Ctr, Lawson Res Inst, Dept Nucl Med & Magnet Resonance, London, ON N6A 4V2, Canada Univ Western Ontario LondonON Canada N6A 4V2 London, ON N6A 4V2, Canada Univ Western Ontario, St Josephs Hlth Ctr, Dept Med Biophys, Div Cardiol, London, ON N6A 4V2, Canada Univ Western Ontario London ON Canada N6A 4V2 London, ON N6A 4V2, Canada
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
fascicolo: 5, volume: 17, anno: 2001,
pagine: 395 - 404
SICI:
0167-9899(200109)17:5<395:TUOGAA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE; EXTRACTION EFFICIENCY; CONTRAST ENHANCEMENT; STUNNED MYOCARDIUM; RELAXATION-TIMES; IN-VIVO; QUANTIFICATION; PERFUSION; ISCHEMIA; MRI;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Prato, FS Univ Western Ontario, St Josephs Hlth Ctr, Lawson Res Inst, DeptNucl Med & Magnet Resonance, 268 Grosvenor St, London, ON N6A 4V2, Canada Univ Western Ontario 268 Grosvenor St London ON Canada N6A 4V2 a
Citazione:
R.S. Pereira et al., "The use of Gd-DTPA as a marker of myocardial viability in reperfused acutemyocardial infarction", INT J CARDI, 17(5), 2001, pp. 395-404

Abstract

At present, accurate assessment of the extent of myocardial viability after acute myocardial infarction is limited due to the spatial resolution of currently available imaging modalities. MR cardiac imaging, with its superior spatial resolution, would be used if viable and infarcted tissue could beseparated based on signal intensity. In infarcted tissue, cell membrane breakdown allows the entry of the MR contrast agent Gd-DTPA which is normallyextracellular. The increased space for Gd-DTPA distribution (partition coefficient, lambda) in this infarcted tissue results in increased Gd-DTPA concentration and hence increased signal intensity on T-1-weighted MR images. In a canine model of ischemia/reperfusion injury, the partition coefficientin infarcted tissue increased as early as 1 min post reperfusion. lambda in infarcted tissue stayed increased over that in normal tissue for at least8 weeks. The accuracy of contrast-enhanced MRI was confirmed by results of(2)01Tl SPECT and a cine MRI dobutamine wall motion study in a patient 1 week after an acute myocardial infarction. Thus, contrast-enhanced MRI showsgreat promise for the non-invasive determination of myocardial viability after acute myocardial infarction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:32:13