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Titolo:
Relationship between function and perfusion early after acute myocardial infarction
Autore:
Lombardi, M; Kvaerness, J; Torheim, G; Soma, J; Cellerini, F; Consalvo, M; Landini, MC; Cecchi, CA; Michelassi, C; Skjaerpe, T; Jones, RA; Rinck, PA; LAbbate, A;
Indirizzi:
CNR, Inst Clin Physiol, MRI Lab, Area Ric S Cataldo, I-56123 Pisa, Italy CNR Pisa Italy I-56123 MRI Lab, Area Ric S Cataldo, I-56123 Pisa, Italy Univ Trondheim Hosp, Dept Med, Cardiol Sect, N-7006 Trondheim, Norway UnivTrondheim Hosp Trondheim Norway N-7006 ct, N-7006 Trondheim, Norway Univ Trondheim Hosp, Med Sect, MR Ctr, N-7006 Trondheim, Norway Univ Trondheim Hosp Trondheim Norway N-7006 tr, N-7006 Trondheim, Norway Santa Maria Nuova Hosp, Radiol Unit, Florence, Italy Santa Maria Nuova Hosp Florence Italy osp, Radiol Unit, Florence, Italy Santa Maria Nuova Hosp, Cardiol Unit Florence, Florence, Italy Santa MariaNuova Hosp Florence Italy ol Unit Florence, Florence, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
fascicolo: 5, volume: 17, anno: 2001,
pagine: 383 - 393
SICI:
0167-9899(200109)17:5<383:RBFAPE>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR-MAGNETIC-RESONANCE; CORONARY-ARTERY DISEASE; GD-DTPA; STRESS ECHOCARDIOGRAPHY; THROMBOLYTIC THERAPY; RELAXATION TIMES; GADOLINIUM-DTPA; BLOOD-FLOW; MRI; VIABILITY;
Keywords:
magnetic resonance imaging; myocardial infarction; myocardial perfusion; viable myocardium;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Lombardi, M CNR, Inst Clin Physiol, MRI Lab, Area Ric S Cataldo, I-56123 Pisa, Italy CNR Pisa Italy I-56123 ea Ric S Cataldo, I-56123 Pisa, Italy
Citazione:
M. Lombardi et al., "Relationship between function and perfusion early after acute myocardial infarction", INT J CARDI, 17(5), 2001, pp. 383-393

Abstract

To assess the relationship between baseline left ventricle function, functional reserve and resting myocardial perfusion in patients with acute myocardial infarction (AMI). After AMI the presence of dysfunctioning but viablemyocardium plays a determinant role in clinical outcome. Regional ventricular function was evaluated by echocardiography both in resting conditions and during dobutamine infusion (10 mug/kg/min). Perfusion was assessed by magnetic resonance imaging in a single slice approach where the first pass ofan intravenously injected bolus of gadolinium-based contrast agent was followed through six regions of interest within the myocardium. In each patient a region with normal function was used as reference and the cross-correlation coefficient (CCC), which described the myocardial perfusion relativelyto the reference region (CCC = 1 means equivalent perfusion), was obtainedfor the other five myocardial regions. Twenty-two patients were enrolled into the study. Sixty-one segments had normal function and normal perfusion (CCC = 0.92 +/- 0.23). The perfusion deficit was more marked in the 29 regions with resting akinesia-dyskinesia than in the 20 hypokinetic regions (CCC = 0.71 +/- 0.45 vs. 0.84 +/- 0.23; p < 0.05). Out of the 29 regions with resting akinesia-dyskinesia the 13 segments which showed functional improvement following dobutamine had a higher resting perfusion than the 16 segments which were unresponsive to dobutamine (CCC = 0.83 +/- 0.32 vs. 0.61 +/- 0.52, p < 0.05). Similarly, out of the 20 regions with resting hypokinesia the 11 segments having functional reserve showed an higher resting perfusion than the segments which did not (0.96 +/- 0.21 vs. 0.69 +/- 0.19; p < 0.05). Early after AMI, the perfusion deficit reflects the severity of the mechanical dysfunction. In regions with baseline dyssynergy resting perfusion is, in general, higher when contractile reserve can be elicited by stress-echo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:08:23