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Titolo:
Relationship between regional F-18-fluorodeoxyglucose and N-13 ammonia uptake in normal myocardium assessed by positron emission tomography: Patternsof mismatch and effects of aging
Autore:
Kofoed, KF; Hove, JD; Freiberg, J; Host, U; Hesse, B; Kelbaek, H;
Indirizzi:
Univ Copenhagen, Rigshosp, Ctr Heart, Dept Med B,Sect 9201,PET Res Unit, DK-2100 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark Univ Copenhagen, Rigshosp, Dept Clin Physiol & Nucl Med, Cyclotron & PET Unit, DK-2100 Copenhagen, Denmark Univ Copenhagen Copenhagen Denmark DK-2100 , DK-2100 Copenhagen, Denmark
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
fascicolo: 5, volume: 17, anno: 2001,
pagine: 361 - 370
SICI:
0167-9899(200109)17:5<361:RBRFAN>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY DISEASE; LEFT-VENTRICULAR DYSFUNCTION; HUMAN HEART; REVASCULARIZATION; VIABILITY; METABOLISM; ISCHEMIA; GLUCOSE; PET; NITROGEN-13-AMMONIA;
Keywords:
age; F-18 fluorodeoxyglucose; myocardial viability; N-13 ammonia; positron emission tomography;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kofoed, KF Univ Copenhagen, Rigshosp, Ctr Heart, Dept Med B,Sect 9201,PET Res Unit, Juliane Mariesvej 24, DK-2100 Copenhagen, Denmark Univ CopenhagenJuliane Mariesvej 24 Copenhagen Denmark DK-2100
Citazione:
K.F. Kofoed et al., "Relationship between regional F-18-fluorodeoxyglucose and N-13 ammonia uptake in normal myocardium assessed by positron emission tomography: Patternsof mismatch and effects of aging", INT J CARDI, 17(5), 2001, pp. 361-370

Abstract

Increased regional myocardial F-18 fluorodeoxyglucose ((18)FDG) uptake in relation to N-13 ammonia ((NH3)-N-13) uptake - i.e. glucose metabolism-blood flow 'mismatch' - appears to be a strong indicator of myocardial viability in patients with ischemic heart disease (IHD) and regionally reduced contractile function. Reference values of regional (18)FDG and (NH3)-N-13 uptake have not been determined in healthy subjects with the target age for the development of IHD. We therefore studied healthy middle-aged and old men using positron emission tomography (PET). Twenty-three healthy men aged 51 to83 years of age were studied. (18)FDG and (NH3)-N-13 uptake was quantifiedin 16 myocardial segments with PET and circumferential profile analysis. The relative (18)FDG/(NH3)-N-13 uptake was considerably heterogeneous with (18)FDG uptake consistently higher than (NH3)-N-13 uptake in the left lateral ventricular wall. This regional 'mismatch' pattern was observed in all subjects, but was most prominent in middle-aged men. The observed age-dependency was the result of a progressive increased in (NH3)-N-13 uptake with advancing age in the left ventricular lateral wall. Age-matched reference values of myocardial (18)FDG and (NH3)-N-13 uptake appears to be important for the discrimination between physiological and pathological glucose metabolism-blood flow mismatch assessed by PET and circumferential profile analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:59:40