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Titolo:
Diurnal changes in lung tumor clearance and their relation to NK cell cytotoxicity in the blood and spleen
Autore:
Shakhar, G; Bar-Ziv, I; Ben-Eliyahu, S;
Indirizzi:
Tel Aviv Univ, Dept Psychol, Psychobiol Res Unit, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 s Unit, IL-69978 Tel Aviv, Israel
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 3, volume: 94, anno: 2001,
pagine: 401 - 406
SICI:
0020-7136(20011101)94:3<401:DCILTC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; IN-VIVO; CIRCADIAN-RHYTHMS; METASTATIC SPREAD; COMPROMISES RESISTANCE; IMMUNE-RESPONSES; RATS; INHIBITION; STRESS; SYSTEM;
Keywords:
chronobiology; F344 rats; MADB106 mammary adenocarcinoma; NK cell cytotoxicity; lymphocyte count; diurnal rhythm; lung tumor metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Shakhar, G Tel Aviv Univ, Dept Psychol, Psychobiol Res Unit, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 69978 Tel Aviv, Israel
Citazione:
G. Shakhar et al., "Diurnal changes in lung tumor clearance and their relation to NK cell cytotoxicity in the blood and spleen", INT J CANC, 94(3), 2001, pp. 401-406

Abstract

Natural killer cell cytotoxicity (NKCC) was reported to manifest a circadian rhythm, peaking during wakefulness in both human blood and rat spleen. Using F344 rats, we investigated whether such fluctuations (i) reflect changes in NK cell numbers or in cytotoxicity per cell; (ii) coincide in the blood and spleen; (iii) correspond with clearance of NK-sensitive tumor cells from the lungs and (iv) influence formation of lung metastases. Two rat groups were housed in opposite 12:12 hr lighting regimens. Two hours after theonset of light or dark, both groups were either sacrificed or intravenously inoculated with tumor cells to study the following indices: NKCC and NK cell numbers in the spleen (n = 29) and blood (n = 79), lung clearance of tumor cells (n 142) and lung metastasis (n = 69). The tumor employed, MADB106, is a NK-sensitive mammary adenocarcinoma that metastasizes only to the lungs. The results indicated that, during the dark phase, splenic NKCC increased (37% higher lytic unit [LU](50)) mostly due to a 28.9% higher percentage of NK cells in the spleen. In contrast, blood NKCC decreased by 42.5% (LU20) and this decline was independent of circulating NK cell numbers, which remained constant. Lung tumor clearance increased in the dark (up to 42% lower retention 9 hr after inoculation), but no corresponding changes in the number of metastases were observed 3 weeks later. We conclude that diurnal changes in rats' NKCC are organ-specific, involve changes in both cell distribution and activity and may affect short-term in vivo indices of NK tumoricidal activity. (C) 2001 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:26:44