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Titolo:
Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan
Autore:
Nakadate, H; Yokomori, K; Watanabe, N; Tsuchiya, T; Namiki, T; Kobayshi, H; Suita, S; Tsunematsu, Y; Horikoshi, Y; Hatae, Y; Endo, M; Komada, Y; Eguchi, H; Toyoda, Y; Kikuta, A; Kobayashi, R; Kaneko, Y;
Indirizzi:
Saitama Canc Ctr Hosp, Dept Canc Chemotherapy, Ina, Saitama 3620806, JapanSaitama Canc Ctr Hosp Ina Saitama Japan 3620806 a, Saitama 3620806, Japan Kitasato Univ Hosp, Dept Pediat, Kanagawa, Japan Kitasato Univ Hosp Kanagawa Japan iv Hosp, Dept Pediat, Kanagawa, Japan Japanese Red Cross Med Ctr, Tokyo, Japan Japanese Red Cross Med Ctr Tokyo Japan Red Cross Med Ctr, Tokyo, Japan Kyushu Univ, Fukuoka 812, Japan Kyushu Univ Fukuoka Japan 812Kyushu Univ, Fukuoka 812, Japan Natl Childrens Hosp, Tokyo 154, Japan Natl Childrens Hosp Tokyo Japan 154 atl Childrens Hosp, Tokyo 154, Japan Shizuoka Childrens Hosp, Shizuoka, Japan Shizuoka Childrens Hosp Shizuoka Japan Childrens Hosp, Shizuoka, Japan Natl Sapporo Hosp, Sapporo, Hokkaido, Japan Natl Sapporo Hosp Sapporo Hokkaido Japan Hosp, Sapporo, Hokkaido, Japan Iwate Med Coll, Morioka, Iwate, Japan Iwate Med Coll Morioka Iwate JapanIwate Med Coll, Morioka, Iwate, Japan Mie Univ, Mie, Japan Mie Univ Mie JapanMie Univ, Mie, Japan Kurume Univ, Kurume, Fukuoka 830, Japan Kurume Univ Kurume Fukuoka Japan 830 ume Univ, Kurume, Fukuoka 830, Japan Kanagawa Childrens Med Ctr, Yokohama, Kanagawa, Japan Kanagawa Childrens Med Ctr Yokohama Kanagawa Japan hama, Kanagawa, Japan Fukushima Med Coll, Fukushima, Japan Fukushima Med Coll Fukushima JapanFukushima Med Coll, Fukushima, Japan Hokkaido Univ, Sapporo, Hokkaido, Japan Hokkaido Univ Sapporo Hokkaido Japan aido Univ, Sapporo, Hokkaido, Japan
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 3, volume: 94, anno: 2001,
pagine: 396 - 400
SICI:
0020-7136(20011101)94:3<396:MOTWGL>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUTATIONS; DELETION; ABNORMALITIES; EXPRESSION;
Keywords:
Wilms' tumor; WT1 deletion/mutation; loss of heterozygosity; chromosomal ploidy; Japan;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Kaneko, Y Saitama Canc Ctr Hosp, Dept Canc Chemotherapy, Ina, Saitama 3620806, Japan Saitama Canc Ctr Hosp Ina Saitama Japan 3620806 3620806, Japan
Citazione:
H. Nakadate et al., "Mutations/deletions of the WT1 gene, loss of heterozygosity on chromosome arms 11p and 11q, chromosome ploidy and histology in Wilms' tumors in Japan", INT J CANC, 94(3), 2001, pp. 396-400

Abstract

Incidence rates of Wilms' tumor (WT) markedly differ in East Asian and Caucasian children. In the present study, we examined WTI deletions/mutations and loss of heterozygosity (LOH) on I I p and I Iq in a large number of WTsand compared our findings with those from 4 series of Caucasian WTs. Incidence rates of the subtle WTI mutation in 3 of the 5 series of sporadic and unilateral WTs including ours were 4.3-6.2% and similar. However, gross homozygous WTI deletion was more frequent in our series than in some others. In addition, our series tended to show a higher incidence of LOH limited to I I p 13 and a lower incidence of LOH including I I p IS than the Caucasianone. These findings indicate some genetic differences in WT between the 2 regions. One of the 4 Caucasian series reported a correlation of germinal WTI mutation with the predominantly stromal histology. The present study notonly confirms the correlation of germinal WTI deletion/mutation with predominant stromal histology but also establishes a correlation with somatic WTI deletion/mutations with predominant stromal histology. While WTs with WTIabnormalities usually showed pseudo-diploidy and predominant stromal histology, those without WTI abnormalities showed various chromosome numbers andhistologic subtypes. (C) 2001 Wiley-Liss, Inc.

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Documento generato il 29/03/20 alle ore 15:26:23