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Titolo:
Interactions of aspirin and salicylic acid with prednisolone for inhibition of lymphocyte proliferation
Autore:
Ramakrishnan, R; Jusko, WJ;
Indirizzi:
SUNY Buffalo, Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, Buffalo, NY14260 USA SUNY Buffalo Buffalo NY USA 14260 pt Pharmaceut Sci, Buffalo, NY14260 USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 11, volume: 1, anno: 2001,
pagine: 2035 - 2042
SICI:
1567-5769(200110)1:11<2035:IOAASA>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; WHOLE-BLOOD; ACETYLSALICYLIC-ACID; SEX; DRUGS; ALPHA; IMMUNOSUPPRESSION; GLUCOCORTICOIDS; PROSTAGLANDINS; MODULATION;
Keywords:
aspirin; salicylic acid; prednisolone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Jusko, WJ SUNY Buffalo, Sch Pharm & Pharmaceut Sci, Dept Pharmaceut Sci, 565 Hochstetter Hall, Buffalo, NY 14260 USA SUNY Buffalo 565 Hochstetter Hall Buffalo NY USA 14260 14260 USA
Citazione:
R. Ramakrishnan e W.J. Jusko, "Interactions of aspirin and salicylic acid with prednisolone for inhibition of lymphocyte proliferation", INT IMMUNO, 1(11), 2001, pp. 2035-2042

Abstract

The anti-inflammatory properties of salicylates and prednisolone were investigated using inhibition of in vitro phytohemagglutinin-stimulated lymphocyte proliferation in human whole blood from healthy male and female subjects. Steroids and salicylates are used in conjunction for the treatment of inflammatory disorders such as rheumatoid arthritis and inhibit the proinflammatory transcription factor, NT kappaB, by different mechanisms. Data generated using various combinations of these drugs were analyzed using isobolograms and the universal surface response approach based on the Loewe additivity principle. The interaction between aspirin and prednisolone was mildly antagonistic while that between salicylic acid and prednisolone was modestly synergistic at therapeutic concentrations. Further, aspirin was slightly more potent in males, but the nature of the steroid-salicylate interaction was similar across genders. This study helps rationalize part of the beneficial effects of steroids and salicylates in treatment of inflammatory disorders. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 20:23:00