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Titolo:
Gender-dependent immunosuppression following subacute exposure to fumonisin B-1
Autore:
Johnson, VJ; Sharma, RP;
Indirizzi:
Univ Georgia, Coll Vet Med, Dept Physiol & Pharmacol, Athens, GA 30602 USAUniv Georgia Athens GA USA 30602 hysiol & Pharmacol, Athens, GA 30602 USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 11, volume: 1, anno: 2001,
pagine: 2023 - 2034
SICI:
1567-5769(200110)1:11<2023:GIFSET>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUSARIUM-MONILIFORME; CULTURE MATERIAL; TOXICITY; CORN; RECEPTOR; CANCER; MYCOTOXINS; EXPRESSION; RESPONSES; APOPTOSIS;
Keywords:
fumonisin; FB1; IL-2; immunosuppression; lymphocyte proliferation; T-lymphocyte; gender-dependent toxicity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Sharma, RP Univ Georgia, Coll Vet Med, Dept Physiol & Pharmacol, Athens, GA 30602 USA Univ Georgia Athens GA USA 30602 armacol, Athens, GA 30602 USA
Citazione:
V.J. Johnson e R.P. Sharma, "Gender-dependent immunosuppression following subacute exposure to fumonisin B-1", INT IMMUNO, 1(11), 2001, pp. 2023-2034

Abstract

The effects of fumonisin B-1 (FB1), a mycotoxin produced by Fusarium vertcillioides, on the immune system are controversial; FB1 exposure causing immunosuppression in poultry, swine, bovine and rodents species and immunostimulation in rodent species. The current study was conducted to examine the effects of FB1 on the immune system of BALB/c mice and to determine if thereis sex specificity. Female and male mice (five per group) received five daily subcutaneous (s.c.) injections of 2.25 mg/kg/day of FB1, on the following day tissues were collected for immunological examinations. FB1 treatmentdramatically reduced relative spleen and thymus weights in females, whereas there was no effect on organ weights in males. Exposure to FB1 reduced splenic cellularity and the basal rate of lymphocyte proliferation in femalesonly. In addition, phytohemagglutinin (PHA-P)-induced T-lymphocyte and LPS-induced B-lymphocyte proliferation were reduced in female mice. Splenocytes from female mice exposed to FB1 showed a reduced expression of interleukin-2 mRNA. These changes occurred in the absence of alterations in tumor necrosis factor alpha or interleukin-1 beta mRNA expression. Phenotypic analysis indicated that FB1 treatment caused a relative increase in the T-lymphocyte population in the spleen of female mice only. In contrast, FB1 dramatically reduced the immature CD4(+)/CD8(+) double positive cell population in the thymus of females. No changes were evident in the thymocyte populationsof male mice treated with FB1. The results of this study indicate that FB1is immunosuppressive in mice; the magnitude of FB1-induced immunosuppression is highly dependent on sex, females being more susceptible than males. (C) 2001 Elsevier Science B.V. All rights reserved.

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Documento generato il 25/01/20 alle ore 19:45:43