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Titolo:
Inmunoferon (R), a glycoconjugate of natural origin, inhibits LPS-induced TNF-alpha production and inflammatory responses
Autore:
Brieva, A; Guerrero, A; Alonso-Lebrero, JL; Pivel, JP;
Indirizzi:
Ind Farmaceut Cantabria SA, R&D Dept, Madrid 28028, Spain Ind Farmaceut Cantabria SA Madrid Spain 28028 Dept, Madrid 28028, Spain
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 11, volume: 1, anno: 2001,
pagine: 1979 - 1987
SICI:
1567-5769(200110)1:11<1979:I(AGON>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; HUMAN-MONOCYTES; ENDOTHELIAL-CELLS; ENDOTOXIN; RELEASE; EXPRESSION; ACTIVATION; TOXICITY; CYTOKINE; SEPSIS;
Keywords:
glycoconjugate; TNF-alpha; IL-6; corticosteroids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Pivel, JP Ind Farmaceut Cantabria SA, R&D Dept, C Azcona 46, Madrid 28028,Spain Ind Farmaceut Cantabria SA C Azcona 46 Madrid Spain 28028 Spain
Citazione:
A. Brieva et al., "Inmunoferon (R), a glycoconjugate of natural origin, inhibits LPS-induced TNF-alpha production and inflammatory responses", INT IMMUNO, 1(11), 2001, pp. 1979-1987

Abstract

We have analyzed the effect of a patented glycoconjugate (GC) of natural origin, Inmunoferon (R), in the development of the response to endotoxemia induced by administration of LPS in rodents. We have observed that oral treatment with the drug reduced the levels of serum TNF-alpha induced by an intravenous pulse of LPS. The serum of pretreated mice blocked TNF-alpha production by peritoneal macrophages. The drug increased the levels of TNF-alpharegulators such as IL-10 and corticosteroids, whereas it inhibited TNF-alpha -dependent IL-6 production. Further TNF-alpha -dependent responses, suchas cell extravasation, was decreased in treated mice. According to these results, Inmunoferon (R) is postulated as an inhibitor of the systemic response to LPS. Correlation of the observations made in mice, with a rat model suggests the efficacy of this product in reducing TNF-alpha production in a species-independent fashion and opens the possibility of its trial as an adjuvant of antibiotics in treatment against gram-negative bacterial infection. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 07:30:45