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Titolo:
Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells
Autore:
Han, SB; Park, SH; Lee, KH; Lee, CW; Lee, SH; Kim, HC; Kim, YS; Lee, HS; Kim, HM;
Indirizzi:
KRIBB, Taejon 305600, South Korea KRIBB Taejon South Korea 305600KRIBB, Taejon 305600, South Korea Korea Res Inst Chem Technol, Taejon 305606, South Korea Korea Res Inst Chem Technol Taejon South Korea 305606 05606, South Korea
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 11, volume: 1, anno: 2001,
pagine: 1969 - 1978
SICI:
1567-5769(200110)1:11<1969:PIFTRO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUSHROOM PHELLINUS-LINTEUS; MEDIATED RESPONSES; LENTINAN; ANGELAN; TUMORS; RATS; MICE; IMPROVEMENT; INHIBITION; COMPLEMENT;
Keywords:
Platycodon grandiflorum; polysaccharide; B cells; macrophages; T cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, HM KRIBB, POB 115, Taejon 305600, South Korea KRIBB POB 115 Taejon South Korea 305600 aejon 305600, South Korea
Citazione:
S.B. Han et al., "Polysaccharide isolated from the radix of Platycodon grandiflorum selectively activates B cells and macrophages but not T cells", INT IMMUNO, 1(11), 2001, pp. 1969-1978

Abstract

Many polysaccharides isolated from plants are considered to be biological response modifiers and have been shown to enhance various immune responses in vivo and in vitro. Here, we demonstrate that polysaccharide isolated from the radix of Platycodon grandiflorum (PG) has a unique mode of immunostimulation with regard to its cell-type specificity. PG was found to markedly increase polyclonal IgM antibody production and the proliferation of B cells, and to activate iNOS transcription and NO production in macrophages. Moreover, the intraperitoneal administration of PG in mice resulted in increased IgM antibody production in B cells, which were immunized by using T-dependent antigen sheep red blood cells (sRBCs). However, PG did not affect theproliferation of T cells, the IL-2 expression of Th1 cells, or the IL-4 expression of Th2 cells. Although PG and lipopolysaccharide (LPS) had a similar mode of action in B cells and macrophages, they were differentiated by the fact that PO-induced cellular activation was not inhibited by polymyxin B, a specific inhibitor of LPS. Anti-CD19 or anti-CD79b antibody blocked B cell proliferation and anti-CD14 or anti-CD11b antibody decreased macrophage NO production, indicating the possible cellular binding sites of PG. Our results demonstrate that PG is a specific activator of B cells and macrophages but not of T cells, and suggest that PG is quite distinct from other well-known immuno stimulants, such as lentinan and schizophyllan, which mainly act upon macrophages and T cells. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:41:21