Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The effects of a Chinese herb formula, anti-cancer number one (ACNO), on NK cell activity and tumor metastasis in rats
Autore:
Li, HF; Waisman, T; Maimon, Y; Shakhar, K; Rosenne, E; Ben-Eliyahu, S;
Indirizzi:
Tel Aviv Univ, Dept Psychol, Psychobiol Res Unit, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 s Unit, IL-69978 Tel Aviv, Israel Tel Aviv Med Ctr & Sch Med, Complementary Med Unit, Tel Aviv, Israel Tel Aviv Med Ctr & Sch Med Tel Aviv Israel y Med Unit, Tel Aviv, Israel
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 11, volume: 1, anno: 2001,
pagine: 1947 - 1956
SICI:
1567-5769(200110)1:11<1947:TEOACH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; CYTO-TOXICITY; HEPATOCELLULAR-CARCINOMA; POLYSACCHARIDE FRACTION; COMPROMISES RESISTANCE; ADRENERGIC-MECHANISMS; ANESTHETIZED RATS; LUNG METASTASIS; SHOSAIKO-TO; IN-VIVO;
Keywords:
Chinese medicine; cancer; natural killer; MADB 106; Ginseng; astragalus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Ben-Eliyahu, S Tel Aviv Univ, Dept Psychol, Psychobiol Res Unit, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 8 Tel Aviv, Israel
Citazione:
H.F. Li et al., "The effects of a Chinese herb formula, anti-cancer number one (ACNO), on NK cell activity and tumor metastasis in rats", INT IMMUNO, 1(11), 2001, pp. 1947-1956

Abstract

The effects of anti-cancer number one (ACNO), a 19-herb Chinese formula used to treat cancer patients, were studied in F344 rats. In the first study,the number and activity of circulating NK cells were evaluated following 18 days of oral consumption of 0.1, 0.5, or 2 g/kg/day. The second study assessed the effect of ACNO on resistance to metastasis of the MADB106 tumor line, a syngeneic mammary adenocarcinoma that metastasizes only to the lungsand is highly sensitive to NK activity (NKA) in vivo. Resistance to metastasis was assessed under baseline conditions and following the administration of a beta -adrenergic agonist, metaproterenol (MP). MP was used to simulate sympathetic response to stressful conditions, and was previously shown to suppress resistance to MADB106 metastasis. The results of the first studyindicated a dose-dependent increase in NKA per ml of blood and per NK cell, with no significant changes in blood concentration of NK cells. In the second study, whereas MP caused a 4.5-fold increase in the number of metastases in untreated rats, only a 2.3-fold increase occurred in rats treated with ACNO. No significant improvement in baseline levels of resistance to metastasis was observed. These findings indicate the importance of studying ACNO under stressful conditions in patients with potentially metastasizing tumors. This may prove particularly important during the perioperative period,spanning from the detection of the primary tumor to postoperative treatment. During this critical period, psychological and physiological stress responses are known to cause massive immunosuppression, which was suggested to promote metastatic development. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/02/20 alle ore 23:29:29