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Titolo:
Immunosuppressive effects of vermiculine in vitro and in allotransplantation system in vivo
Autore:
Zajicova, A; Muckova, M; Krulova, M; Rychnavska, Z; Holan, V;
Indirizzi:
Acad Sci Czech Republ, Inst Mol Genet, Prague 16637 6, Czech Republic AcadSci Czech Republ Prague Czech Republic 16637 6 37 6, Czech Republic Inst Drug Res, Modra 90001, Slovakia Inst Drug Res Modra Slovakia 90001Inst Drug Res, Modra 90001, Slovakia Charles Univ, Fac Nat Sci, CR-12844 Prague, Czech Republic Charles Univ Prague Czech Republic CR-12844 12844 Prague, Czech Republic
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 11, volume: 1, anno: 2001,
pagine: 1939 - 1945
SICI:
1567-5769(200110)1:11<1939:IEOVIV>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSPLANTATION; DRUGS; MICE;
Keywords:
vermiculine; immunosuppression; cytokines production; cell proliferation; graft survival;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Holan, V Acad Sci Czech Republ, Inst Mol Genet, Flemingovo Nam 2, Prague 16637 6, Czech Republic Acad Sci Czech Republ Flemingovo Nam 2 Prague CzechRepublic 16637 6
Citazione:
A. Zajicova et al., "Immunosuppressive effects of vermiculine in vitro and in allotransplantation system in vivo", INT IMMUNO, 1(11), 2001, pp. 1939-1945

Abstract

Vermiculine, a macrocyclic aglycosidic dilactone, isolated from Penicillium vermiculatum, has been shown to have immunomodulatory properties. Here, we tested the effects of vermiculine on selected parameters of cell-mediatedimmunity in vitro and on skin allograft survival in vivo. Vermiculine inhibited in a dose-dependent manner the proliferation of mouse spleen cells stimulated with Concanavalin A ((Con A), i.e. T-cell mitogen), bacterial lipopolysaccharide ((LPS), B-cell mitogen) or with irradiated allogeneic cells. In addition, vermiculine dose-dependently inhibited the production of Th1 (IL-2, IFN-gamma) and Th2 (IL-4, IL-10) cytokines and suppressed the production of nitric oxide (NO) by activated macrophages. When compared with cyclosporine (CsA), vermiculine was less inhibitory for IL-2 gene expression and IL-2 synthesis, comparably suppressive on IL-10 production and even more inhibitory for NO synthesis. These observations suggest that vermiculine and CsA inhibit immune reactions by different mechanisms. Treatment of graft recipients with vermiculine or CsA prolonged survival of skin allografts ina mouse model. The combination of both drugs enhanced the survival of allografts significantly more than either drug alone. The results thus suggest that vermiculine is a potential immunosuppressive drug acting by a mechanism distinct from that of CsA, and thus it may be used alone or in combination with other drugs for immunoregulatory purposes. (C) 2001 Elsevier ScienceB.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/02/20 alle ore 20:39:33