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Titolo:
17-beta-estradiol alters Jurkat lymphocyte cell cycling and induces apoptosis through suppression of Bcl-2 and cyclin A
Autore:
Jenkins, JK; Suwannaroj, S; Elbourne, KB; Ndebele, K; McMurray, RW;
Indirizzi:
Univ Mississippi, Med Ctr, Dept Med, Div Rheumatol Mol Immunol, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 Mol Immunol, Jackson, MS 39216 USA GV Sonny Montgomery VA Hosp, Dept Med, Div Rheumatol, Jackson, MS 39216 USA GV Sonny Montgomery VA Hosp Jackson MS USA 39216 l, Jackson, MS 39216 USA
Titolo Testata:
INTERNATIONAL IMMUNOPHARMACOLOGY
fascicolo: 11, volume: 1, anno: 2001,
pagine: 1897 - 1911
SICI:
1567-5769(200110)1:11<1897:1AJLCC>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYSTEMIC LUPUS-ERYTHEMATOSUS; T-CELLS; RECEPTOR ANTAGONIST; ESTROGEN-RECEPTORS; ANTIGEN RECEPTOR; HUMAN MONOCYTES; MODEL SYSTEM; DEATH; MECHANISMS; ACTIVATION;
Keywords:
estrogen; progesterone; T lymphocytes; cell cycle; apoptosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Jenkins, JK Univ Mississippi, Med Ctr, Dept Med, Div Rheumatol Mol Immunol, L525,2500 N State St, Jackson, MS 39216 USA Univ Mississippi L525,2500 N State St Jackson MS USA 39216 USA
Citazione:
J.K. Jenkins et al., "17-beta-estradiol alters Jurkat lymphocyte cell cycling and induces apoptosis through suppression of Bcl-2 and cyclin A", INT IMMUNO, 1(11), 2001, pp. 1897-1911

Abstract

In this investigation, the effects and potential mechanisms of female sex steroid action on proliferation, cell cycling, and apoptosis in Jurkat CD4 T lymphocytes were examined. 17-beta -Estradiol (estrogen) inhibited Jurkat T cell proliferation, stimulated accumulation of cells in S and G(2)/M Phases of the cell cycle, and induced apoptosis over 72 h in a dose-dependent manner. 4-Pregnene-3,20-dione (progesterone) did not induce redistribution of the cells in the cell cycle but did induce cytostasis and slightly increased apoptosis. Simultaneous staining with anti-BrDU and propidium iodideindicated that estrogen-treated Jurkat T cells proceeded through S phase prior to apoptosis. Progesterone halted cell cycle progression; cells did not progress through S phase or incorporate BrDU. Both hormones decreased thepercentage of cells in S or G(2)/M expressing cyclin A protein, but did not affect cyclin D protein expression. Cyclin A mRNA was markedly decreased by estrogen. Bcl-2 protein and mRNA were also reduced in estrogen but not progesterone-treated Jurkat T lymphocytes. This data shows that high concentrations of estrogen or progesterone significantly suppress lymphoproliferation in association with suppression of cyclin A. Additionally, bcl-2 protein levels were suppressed in association with estrogen-induced apoptosis. These findings demonstrate direct, hormone-specific effects on lymphocytes that may provide insight into their role in immunomodulation or the development of autoimmunity. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 09:34:32