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Titolo:
The effect of a bradykinin B-2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model
Autore:
Sylvin, H; van der Ploeg, I; Alving, K;
Indirizzi:
Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 ol, SE-17177 Stockholm, Sweden St Eriks Eye Hosp, Karolinska Inst, Dept Clin Res, Stockholm, Sweden St Eriks Eye Hosp Stockholm Sweden st, Dept Clin Res, Stockholm, Sweden
Titolo Testata:
INFLAMMATION RESEARCH
fascicolo: 9, volume: 50, anno: 2001,
pagine: 453 - 459
SICI:
1023-3830(200109)50:9<453:TEOABB>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BRONCHOCONSTRICTION; NEDOCROMIL SODIUM; HISTAMINE-RELEASE; BRONCHIAL-ASTHMA; SUBSTANCE-P; MAST-CELLS; TRYPTASE; PIG; VASODILATATION; KININOGENS;
Keywords:
swine; bradykinin; NPC-567; Ascaris suum; mast cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Sylvin, H Karolinska Inst, Dept Physiol & Pharmacol, SE-17177 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 77 Stockholm, Sweden
Citazione:
H. Sylvin et al., "The effect of a bradykinin B-2 receptor antagonist, NPC-567, on allergen-induced airway responses in a porcine model", INFLAMM RES, 50(9), 2001, pp. 453-459

Abstract

Objective and design: In order to assess the effect of selective blocking of the bradykinin (BK) BZ receptor in allergic airway reactions, the BK B-2receptor antagonist NPC-567 was administered to sensitized pigs before allergen challenge. Material: Fourteen specific pathogen-free pigs sensitized to Ascaris suum were used. Treatment: NPC-567 (2.5 mg, in 1 ml saline) was delivered as an aerosol twice to six pigs. Methods: Ascaris antigen (in 2 ml saline) was given as an aerosol to all pigs and airway mechanics were monitored for 8 h. NPC-567 (2.5 mg) was givenat t = -30 min (in 1 ml saline) and mixed with the antigen at t = 0 to sixpigs. Results: Allergen challenge caused an acute reaction with a rapid, significant increase in airways resistance from 4.1 +/- 0.5 cm H2O/l/s to a maximum of 16.2 +/- 3.0 cmH(2)O/l/s in the control pigs. In the NPC-567-treated pigs, the resistance only increased from 2.9 +/- 0.3 cm H2O/l/s to 6.5 +/- 0.9 cm H2O/l/s (p <0.005 compared to controls). There was also a higher reduction in dynamic lung compliance in the controls than in the treated animals upon allergen challenge. The histamine concentration in urine in the control pigs was markedly elevated after allergen challenge peaking at 15-30 min. This release was inhibited in the NPC-567-treated pigs. Conclusions: The BK B-2 receptor antagonist NPC-567 seems to be effective in inhibiting the acute response to allergen in the pig airways, possibly due to inhibition of mast cell activation via indirect mechanisms. The late obstructive response was reduced as well, probably as a consequence of the reduced mediator release in the acute reaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 19:43:20