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Titolo:
Serum 18-hydroxycortisol in primary aldosteronism, hypertension, and normotensives
Autore:
Mosso, L; Gomez-Sanchez, CE; Foecking, MF; Fardella, C;
Indirizzi:
Pontificia Univ Catolica Chile, Fac Med, Dept Endocrinol, Santiago, Chile Pontificia Univ Catolica Chile Santiago Chile docrinol, Santiago, Chile Univ Mississippi, Med Ctr, Div Endocrinol, Jackson, MS 39216 USA Univ Mississippi Jackson MS USA 39216 v Endocrinol, Jackson, MS 39216 USA GV Sonny Montgomery VA Med Ctr, Jackson, MS USA GV Sonny Montgomery VA MedCtr Jackson MS USA A Med Ctr, Jackson, MS USA Harry S Truman VA Med Ctr, Columbia, MO USA Harry S Truman VA Med Ctr Columbia MO USA n VA Med Ctr, Columbia, MO USA
Titolo Testata:
HYPERTENSION
fascicolo: 3, volume: 38, anno: 2001,
parte:, 2 supplemento:, S
pagine: 688 - 691
SICI:
0194-911X(200109)38:3<688:S1IPAH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCOCORTICOID-REMEDIABLE ALDOSTERONISM; SUPPRESSIBLE HYPERALDOSTERONISM; CHIMERIC GENE; 18-OXOCORTISOL; DIAGNOSIS; DEXAMETHASONE; PHENOTYPE; EXCRETION; STEROIDS; BINDING;
Keywords:
18-hydroxycortisol; hypertension, mineralocorticoid; glucocorticoids; aldosterone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Mosso, L Pontificia Univ Catolica Chile, Fac Med, Dept Endocrinol, Lira 442 Piso, Santiago, Chile Pontificia Univ Catolica Chile Lira 44 2 Piso Santiago Chile le
Citazione:
L. Mosso et al., "Serum 18-hydroxycortisol in primary aldosteronism, hypertension, and normotensives", HYPERTENSIO, 38(3), 2001, pp. 688-691

Abstract

This study reports the determination of plasma 18-hydroxycortisol (18-OHF)using a new and easy enzyme-linked immunosorbent assay (ELISA) method in primary aldosteronism and compares the values found in essential hypertensives and normotensive controls. In primary aldosteronism, we evaluated usefulness of plasma 18-OHF determination and the dexamethasone suppression test in the diagnosis of glucocorticoid-remediable aldosteronism using the genetic test as the gold standard. We studied 31 primary aldosteronism patients,101 essential hypertensives, and 102 healthy normotensive controls. The plasma 18-OHF was measured using a biotin-avidin enzyme-linked assay by a newand purified polyclonal antibody. The 18-OHF value in primary aldosteronism was 6.3 +/- 8.05 nmol/L; this value is significantly higher than the value found in essential hypertensives and normotensive controls (2.81 +/- 1.42and 2.70 +/- 1.41 nmol/L, respectively; P <0.0005). In primary aldosteronism, 4 of 31 patients had 18-OHF levels that were 10 times higher than the normal upper limit (2.983 nmol/L). The dexamethasone suppression test in primary aldosteronism patients was positive (serum aldosterone <4 ng/dL) in 13of 31 cases. A chimeric CYP11B1/CYP11B2 gene was demonstrated in 4 primaryaldosteronism patients, corresponding to the same cases that had higher level of 18-OHF. In conclusion, plasma 18-OHF determination by this ELISA method is reliable for detecting glucocorticoid-remediable aldosteronism, and it does so better than the dexamethasone suppression test.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 11:05:57