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Titolo:
Role of the medulla oblongata in hypertension
Autore:
Colombari, E; Sato, MA; Cravo, SL; Bergamaschi, CT; Campos, RR; Lopes, OU;
Indirizzi:
UNIFESP, EPM, Dept Physiol, BR-04023060 Sao Paulo, Brazil UNIFESP Sao Paulo Brazil BR-04023060 BCol, BR-04023060 Sao Paulo, Brazil
Titolo Testata:
HYPERTENSION
fascicolo: 3, volume: 38, anno: 2001,
parte:, 2 supplemento:, S
pagine: 549 - 554
SICI:
0194-911X(200109)38:3<549:ROTMOI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAUDAL VENTROLATERAL MEDULLA; NUCLEUS-TRACTUS-SOLITARII; SYMPATHETIC-NERVE ACTIVITY; BARORECEPTOR-DENERVATED RATS; EXCITATORY AMINO-ACIDS; BRAIN-STEM; BLOOD-PRESSURE; CARDIOVASCULAR-RESPONSES; NORADRENERGIC NEURONS; ARTERIAL-PRESSURE;
Keywords:
brain; chemoreceptors; homeostasis; hypertension, experimental; sympathetic nervous system; nitric oxide; angiotensin; sympathectomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Colombari, E UNIFESP, EPM, Dept Physiol, Rua Botucatu 862, BR-04023060 SaoPaulo, Brazil UNIFESP Rua Botucatu 862 Sao Paulo Brazil BR-04023060 BCazil
Citazione:
E. Colombari et al., "Role of the medulla oblongata in hypertension", HYPERTENSIO, 38(3), 2001, pp. 549-554

Abstract

Brain pathways controlling arterial pressure are distributed throughout the neuraxis and are organized in topographically selective networks. In thisbrief review, we will focus on the medulla oblongata. The nucleus tractus solitarius (NTS) is the primary site of cardiorespiratory reflex integration. It is well accepted that lesions or other perturbations in the NTS can result in elevations of arterial pressure (AP), with many of the associated features so commonly found in humans. However, recent studies have shown 2 distinct subpopulations of neurons within the NTS that can influence AP in opposite ways. Commissural NTS neurons located on the midline may contribute to maintenance of hypertension in spontaneously hypertensive rats (SHR), because small lesions in this area result in a very significant reduction in AP. Also involved in this blood pressure regulation network are 2 distinct regions of the ventrolateral medulla: caudal (CVLM) and rostral (RVLM). Neurons in CVLM are thought to receive baroreceptor input and to relay rostrally to control the activity of the RVLM. Projections from CVLM to RVLM areinhibitory, and a lack of their activity may contribute to development of hypertension. The RVLM is critical to the tonic and reflexive regulation ofAP. In different experimental models of hypertension, RVLM neurons receivesignificantly more excitatory inputs. This results in enhanced sympatheticneuronal activity, which is essential for the development and maintenance of the hypertension.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/10/20 alle ore 21:41:44