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Titolo:
Functional neuroanatomy of visuo-spatial working memory in Turner syndrome
Autore:
Haberecht, MF; Menon, V; Warsofsky, IS; White, CD; Dyer-Friedman, J; Glover, GH; Neely, EK; Reiss, AL;
Indirizzi:
Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford Psychiat Neuroimaging Lab, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 roimaging Lab, Stanford, CA 94305 USA Stanford Univ, Sch Med, Program Neurosci, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 gram Neurosci, Stanford, CA 94305 USA Stanford Univ, Sch Med, Stanford Brain Res Ctr, Stanford, CA 94305 USA Stanford Univ Stanford CA USA 94305 Brain Res Ctr, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Radiol, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Radiol, Stanford, CA 94305 USA Stanford Univ, Sch Med, Dept Pediat, Stanford, CA 94305 USA Stanford UnivStanford CA USA 94305 , Dept Pediat, Stanford, CA 94305 USA
Titolo Testata:
HUMAN BRAIN MAPPING
fascicolo: 2, volume: 14, anno: 2001,
pagine: 96 - 107
SICI:
1065-9471(200110)14:2<96:FNOVWM>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PREFRONTAL CORTEX; BASAL GANGLIA; RHESUS-MONKEY; ACTIVATION; FMRI; TASK; CIRCUITS; OBJECT; DISSOCIATION; BEHAVIOR;
Keywords:
neuroimaging; functional MRI; parietal cortex; prefrontal cortex; caudate; spatial cognition; X monosomy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Haberecht, MF Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Stanford Psychiat Neuroimaging Lab, 401 Quarry Rd, Stanford, CA 94305 USA Stanford Univ 401 Quarry Rd Stanford CA USA 94305 94305 USA
Citazione:
M.F. Haberecht et al., "Functional neuroanatomy of visuo-spatial working memory in Turner syndrome", HUM BRAIN M, 14(2), 2001, pp. 96-107

Abstract

Turner syndrome (TS), a genetic disorder characterized by the absence of an X chromosome in females, has been associated with cognitive and visuo-spatial processing impairments. We utilized functional MRI (fMRI) to investigate the neural substrates that underlie observed deficits in executive functioning and visuo-spatial processing. Eleven females with TS and 14 typically developing females (ages 7-20) underwent fMRI scanning while performing 1-back and 2-back versions of a standard visuo-spatial working memory (WM) task. On both tasks, TS subjects performed worse than control subjects. Compared with controls, TS subjects showed increased activation in the left andright supramarginal gyrus (SMG) during the 1-back task and decreased activation in these regions during the 2-back task. In addition, decreased activation in the left and right dorsolateral prefrontal cortex (DLPFC) and caudate nucleus was observed during the 2-back task in TS subjects. Activation differences localized to the SMG, in the inferior parietal lobe, may reflect deficits in visuo-spatial encoding and WM storage mechanisms in TS. In addition, deficits in the DLPFC and caudate may be related to deficits in executive function during WM performance. Together these findings point to deficits in frontal-striatal and frontal-parietal circuits subserving multipleWM functions in TS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:23:55