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Titolo:
Colorectal neoplasia in ulcerative colitis - recent advances
Autore:
Wong, NACS; Harrison, DJ;
Indirizzi:
Univ Edinburgh, Sch Med, Dept Pathol, Sir Alastair Currie CRC Labs, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9AG Midlothian, Scotland
Titolo Testata:
HISTOPATHOLOGY
fascicolo: 3, volume: 39, anno: 2001,
pagine: 221 - 234
SICI:
0309-0167(200109)39:3<221:CNIUC->2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFLAMMATORY-BOWEL-DISEASE; DNA MISMATCH REPAIR; MICROSATELLITE INSTABILITY; CROHNS-DISEASE; POLYPOID DYSPLASIA; SPORADIC ADENOMAS; COLON-CANCER; BETA-CATENIN; CYCLIN D1; GENETIC ALTERATIONS;
Keywords:
ulcerative colitis; colorectal neoplasms; adenocarcinoma; dysplasia; adenoma; molecular biology; diagnostic tests; lymphoma; sarcoma; carcinoid tumour;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Wong, NACS Univ Edinburgh, Sch Med, Dept Pathol, Sir Alastair Currie CRC Labs, TeviotPl, Edinburgh EH8 9AG, Midlothian, Scotland Univ Edinburgh Teviot Pl Edinburgh Midlothian Scotland EH8 9AG
Citazione:
N.A.C.S. Wong e D.J. Harrison, "Colorectal neoplasia in ulcerative colitis - recent advances", HISTOPATHOL, 39(3), 2001, pp. 221-234

Abstract

It is recognized that ulcerative colitis (UC) predisposes to the development of colorectal adenocarcinoma (CRC), and the molecular pathway for this process differs from that for sporadic CRCs. However, several important details regarding the risk factors for and the molecular changes underlying UC-related colorectal carcinogenesis have only come to light lately. First, recent data suggest environmental factors related to long-standing inflammation contribute more to this increased cancer risk than an inherited susceptibility. Second, molecular changes that may represent the first steps in thedevelopment of neoplasia are being increasingly identified in non-dysplastic, colitic mucosa. Third, there is now good evidence suggesting that UC-related CRC may develop along more than one molecular pathway. These emergingdata will hopefully contribute to attempts to prevent the development of UC-related CRC, e.g. through refining surveillance programmes. Details of the molecular heterogeneity of UC-related dysplasia and CRC may also help develop reliable tools for diagnosing the former and for predicting the behaviour of the latter. Finally, there is increasing awareness of non-epithelialcolorectal malignancies which are associated with UC and may potentially increase in incidence with changes in the medical management of this inflammatory disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 17:42:40