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Titolo:
Immunohistochemical localization of WE-14 in the developing porcine sympathoadrenal cell lineage
Autore:
Barkatullah, SC; Pogue, KM; Depreitere, J; Boutajangout, A; Liang, F; DePotter, W; Curry, WJ;
Indirizzi:
Queens Univ Belfast, Inst Clin Sci, Dept Ophthalmol, Belfast BT12 6BJ, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland BT12 6BJ , North Ireland Queens Univ Belfast, Dept Med, Belfast, Antrim, North Ireland Queens Univ Belfast Belfast Antrim North Ireland , Antrim, North Ireland Univ Antwerp, Dept Med, Neuropharmacol Lab, B-2020 Antwerp, Belgium Univ Antwerp Antwerp Belgium B-2020 armacol Lab, B-2020 Antwerp, Belgium
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 3, volume: 116, anno: 2001,
pagine: 255 - 262
SICI:
0948-6143(200109)116:3<255:ILOWIT>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEVELOPING SYMPATHETIC NEURONS; A-DERIVED PEPTIDES; CHROMOGRANIN-A; TYROSINE-HYDROXYLASE; PRENATAL DEVELOPMENT; NEURAL CREST; PANCREASTATIN; EXPRESSION; SYSTEM; SYNAPTOPHYSIN;
Keywords:
chromogranin A; WE-14; chromaffin cell; ontogeny; pig;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Curry, WJ Queens Univ Belfast, Inst Clin Sci, Dept Ophthalmol, Grosvenor Rd, BelfastBT12 6BJ, Antrim, North Ireland Queens Univ Belfast Grosvenor Rd Belfast Antrim North Ireland BT12 6BJ
Citazione:
S.C. Barkatullah et al., "Immunohistochemical localization of WE-14 in the developing porcine sympathoadrenal cell lineage", HISTOCHEM C, 116(3), 2001, pp. 255-262

Abstract

Immunohistochemical investigation of the post-translational processing of chromogranin A (CgA) to generate WE-14 in the sympathoadrenal cell lineage of the developing porcine fetus (F) detected intense CgA and weak WE-14 immunoreactivity in migrating neuroblast cells of the diffuse sympathetic ganglia adjacent to the dorsal aorta and projecting toward the cortical mass atF24-27. F37-42; WE-14 immunoreactivity was detected in chromaffinoblasts at the periphery of the developing cortex and at F54-56 days gestation WE-14immunoreactivity was detected in a large population of central medullary cells. From F74 to F76 days and thereafter the number of cells exhibiting intense WE-14 immunostaining decreased, and the majority of chromaffin cells exhibited uniform weak WE-14 immunostaining. At postnatal day 1 (P1) intense WE-14 immunoreactivity was primarily confined to clusters of chromaffin cells with weak immunostaining in the general population. The transitory neuroblasts, chromaffinoblasts, and maturing chromaffin cell population exhibited uniform intense C-A immunostaining through gestation and after birth. Additional observations detected intense C-A and WE-14 immunostaining in extrachromaffin tissue at P1 and in neuronal-like cells in vessels of the aortic arch at F37. This study has demonstrated that CgA is post-translationally processed to generate WE-14 during early fetal development in the migrating progenitor cells of the porcine sympathoadrenal lineage.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 04:01:05