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Titolo:
Expression of neural cell adhesion molecule in human liver development andin congenital and acquired liver diseases
Autore:
Libbrecht, L; Cassiman, D; Desmet, V; Roskams, T;
Indirizzi:
Katholieke Univ Leuven, Lab Morphol & Mol Pathol, B-3000 Louvain, Belgium Katholieke Univ Leuven Louvain Belgium B-3000 l, B-3000 Louvain, Belgium Katholieke Univ Leuven, Cell Pharmacol Lab, B-3000 Louvain, Belgium Katholieke Univ Leuven Louvain Belgium B-3000 b, B-3000 Louvain, Belgium
Titolo Testata:
HISTOCHEMISTRY AND CELL BIOLOGY
fascicolo: 3, volume: 116, anno: 2001,
pagine: 233 - 239
SICI:
0948-6143(200109)116:3<233:EONCAM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAHEPATIC BILE-DUCTS; HEPATIC STELLATE CELLS; RAT-LIVER; N-CAM; PROGENITOR CELLS; BILIARY ATRESIA; NCAM; CHOLANGIOCYTES; INNERVATION; PLASTICITY;
Keywords:
liver development; liver cirrhosis; neural cell adhesion molecule; bile duct; ductal plate malformation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Libbrecht, L Katholieke Univ Leuven, Lab Morphol & Mol Pathol, Minderbroedersstr 12, B-3000 Louvain, Belgium Katholieke Univ Leuven Minderbroedersstr12 Louvain Belgium B-3000
Citazione:
L. Libbrecht et al., "Expression of neural cell adhesion molecule in human liver development andin congenital and acquired liver diseases", HISTOCHEM C, 116(3), 2001, pp. 233-239

Abstract

In the liver, neural cell adhesion molecule (NCAM) is a marker of immaturecells committed to the biliary lineage and is expressed by reactive bile ductules in human liver diseases. We investigated the possible role of NCAM in the development of intrahepatic bile ducts and aimed at determining whether immature biliary cells can contribute to the repair of damaged bile ducts in chronic liver diseases. Therefore, we performed immunohistochemistry for NCAM and bile duct cell markers cytokeratin 7 and cytokeratin 19 on frozen sections of 85 liver specimens taken from 14 fetuses, 10 donor livers, 18 patients with congenital liver diseases characterized by ductal plate malformations (DPMs), and 43 cirrhotic explant livers. Duplicated ductal plates and incorporating, bile ducts during development showed a patchy immunoreactivity for NCAM, while DPMs were continuously positive for NCAM. Bile ducts showing complete or patchy immunoreactivity for NCA M were found in cirrhotic livers, with higher frequency in biliary than in posthepatitic cirrhosis. Our results suggest that NCAM may have a function in the development of the intrahepatic bile ducts and that NCAM-positive immature biliary cells can contribute to the repair of damaged bile ducts in chronic liver diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:41:54