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Titolo:
Clinicopathological features of serum TTV DNA-positive non-A-G liver diseases in Japan
Autore:
Sioda, A; Moriyama, M; Matsumura, H; Kaneko, M; Tanaka, N; Arakawa, Y;
Indirizzi:
Nihon Univ, Sch Med, Dept Internal Med 3, Itabashi Ku, Tokyo 1738610, Japan Nihon Univ Tokyo Japan 1738610 Med 3, Itabashi Ku, Tokyo 1738610, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 2, volume: 21, anno: 2001,
pagine: 169 - 180
SICI:
1386-6346(200110)21:2<169:CFOSTD>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPATITIS-G VIRUS; UNKNOWN ETIOLOGY; BLOOD-DONORS; POSTTRANSFUSION HEPATITIS; HEPATOCELLULAR-CARCINOMA; INFECTION; PREVALENCE; CIRRHOSIS; SEQUENCES; GENOME;
Keywords:
TT virus; non-A-G hepatitis; hepatocellular carcinoma; blood donors; liver histology; irregular degeneration of hepatocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Moriyama, M Nihon Univ, Sch Med, Dept Internal Med 3, Itabashi Ku, 30-1 Oyaguchi Kamimachi, Tokyo 1738610, Japan Nihon Univ 30-1 Oyaguchi Kamimachi Tokyo Japan 1738610 Japan
Citazione:
A. Sioda et al., "Clinicopathological features of serum TTV DNA-positive non-A-G liver diseases in Japan", HEPATOL RES, 21(2), 2001, pp. 169-180

Abstract

This study was undertaken to detect TTV DNA in serum samples from patientswith non-A, non-B, non-C, non-E, and non-G (non-A-G) liver diseases and from blood donors, and to investigate the clinicopathological features of TTVinfection including its prevalence and influence on liver disease. The study population consisted of 20 patients with non-A-G liver diseases (nine with chronic hepatitis (CH), six with liver cirrhosis (LC), and five with hepatocellular carcinoma (HCC), as well as 47 blood donors. Detection of TTV DNA was conducted with 200 mul of serum by the nested polymerase chain reaction. The detection rate of TTV DNA by subject category was CH 55.9; LC 66.7; HCC 60%; and blood donors 28%. Regarding blood biochemistry, TTV DNA-positive patients tended to show higher levels of aspartate aminotransferase and alanine amino transferase, as well as lower levels of platelet counts. Long-term follow-up revealed that TTV DNA-positive patients exhibited characteristic, multiple peaks of alanine aminotransferase (ALT) levels. The histologic findings in the livers of TTV DNA-positive patients with CH consistedof moderate necro-inflammatory reactions. In conclusion, it is possible that the TTV genotype 1b infection caused liver injury. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:36:47