Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Anti-fibrogenic effect of an angiotensin converting enzyme inhibitor on chronic carbon tetrachloride-induced hepatic fibrosis in rats
Autore:
Ohishi, T; Saito, H; Tsusaka, K; Toda, K; Inagaki, H; Hamada, Y; Kumagai, N; Atsukawa, K; Ishii, H;
Indirizzi:
Keio Univ, Sch Med, Dept Internal Med, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 d, Dept Internal Med, Tokyo 1608582, Japan Tokyo Metropolitan Hiroo Gen Hosp, Dept Internal Med, Tokyo 1500012, JapanTokyo Metropolitan Hiroo Gen Hosp Tokyo Japan 1500012 kyo 1500012, Japan Saitama Med Coll, Dept Internal Med, Saitama 3500495, Japan Saitama Med Coll Saitama Japan 3500495 ernal Med, Saitama 3500495, Japan Kitasato Inst Hosp, Biores Ctr, Tokyo 1088642, Japan Kitasato Inst Hosp Tokyo Japan 1088642 Biores Ctr, Tokyo 1088642, Japan Kitasato Inst Hosp, Dept Internal Med, Tokyo 1088642, Japan Kitasato Inst Hosp Tokyo Japan 1088642 nternal Med, Tokyo 1088642, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 2, volume: 21, anno: 2001,
pagine: 147 - 158
SICI:
1386-6346(200110)21:2<147:AEOAAC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSFORMING GROWTH FACTOR-BETA(1); FAT-STORING CELLS; GENE-EXPRESSION; MESANGIAL CELLS; STELLATE CELLS; I COLLAGEN; ITO CELLS; LIVER; CIRRHOSIS; MECHANISMS;
Keywords:
rat hepatic stellate cells; angiotensin II; angiotensin-converting enzyme inhibitor; carbon tetrachloride; fibrosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Ishii, H Keio Univ, Sch Med, Dept Internal Med, Tokyo 1608582, Japan Keio Univ Tokyo Japan 1608582 nternal Med, Tokyo 1608582, Japan
Citazione:
T. Ohishi et al., "Anti-fibrogenic effect of an angiotensin converting enzyme inhibitor on chronic carbon tetrachloride-induced hepatic fibrosis in rats", HEPATOL RES, 21(2), 2001, pp. 147-158

Abstract

The tissue renin-angiotensin system has recently been demonstrated to reduce fibrogenesis in various organs. However, little has been clarified regarding its role in hepatic fibrosis. The purpose of this study was to investigate the effect of angiotensin-converting enzyme inhibitors on liver fibrogenesis induced in rats by low-dose chronic carbon tetrachloride administration. We used lisinopril that is absorbed in its active form and not metabolized in the liver to avoid any influence by the administration of the chemical. Carbon tetrachloride was administered twice a week i.p. Twelve and 24 weeks after the start of treatment, expanded periportal fibrosis or portal-portal bridgings and severe fat deposition were observed in the rats treated with carbon tetrachloride alone, and these findings were significantly reduced with the simultaneous treatment with lisinopril. The hydroxyproline content of the liver was significantly lower in the lisinopril-treated group. Angiotensin II up-regulated mRNA of pro alpha (1) collagen and transforming growth factor-beta in isolated hepatic stellate cells. These results suggest that the local tissue renin-angiotensin system plays a role in rat hepatic fibrogenesis induced by chronic carbon tetrachloride administration and that hepatic fibrogenesis is significantly reduced by ACE inhibitors. (C)2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 13:59:52