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Titolo:
Hepatic GABA(A) receptor functional regulation during rat liver cell proliferation
Autore:
Biju, MP; Pyroja, S; Rajeshkumar, NV; Paulose, CS;
Indirizzi:
Cochin Univ Sci & Technol, Ctr Neurosci, Dept Biotechnol, Mol Neurobiol & Cell Biol Unit, Cochin 682022, Kerala, India Cochin Univ Sci & Technol Cochin Kerala India 682022 82022, Kerala, India Amala Canc Res Ctr, Thrissur 680553, Kerala, India Amala Canc Res Ctr Thrissur Kerala India 680553 sur 680553, Kerala, India
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 2, volume: 21, anno: 2001,
pagine: 136 - 146
SICI:
1386-6346(200110)21:2<136:HGRFRD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GAMMA-AMINOBUTYRIC ACID; REGENERATION; AFFINITY; HEPATOCYTES; BINDING; CIPROFLOXACIN; LOCALIZATION; HYPERPLASIA; GROWTH; BRAIN;
Keywords:
GABA receptor; liver regeneration; hyperplasia; liver cancers; hepatocyte;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Paulose, CS Cochin Univ Sci & Technol, Ctr Neurosci, Dept Biotechnol, Mol Neurobiol & Cell Biol Unit, Cochin 682022, Kerala, India Cochin Univ Sci & Technol Cochin Kerala India 682022 a, India
Citazione:
M.P. Biju et al., "Hepatic GABA(A) receptor functional regulation during rat liver cell proliferation", HEPATOL RES, 21(2), 2001, pp. 136-146

Abstract

Gamma aminobutyric acid (GABA(A)) receptor functional status was analysed in partial hepatectomised (PH), lead nitrate (LN) induced hyperplastic and N-nitrosodiethylamine (NDEA) treated neoplastic rat livers during peak DNA synthesis. The high-affinity [H-3]GABA binding significantly decreased in PH and NDEA rats and the receptor affinity decreased in NDEA and increased in LN rats compared with control. In NDEA, displacement analysis of [H-3]GABA with muscimol showed loss of low-affinity site and a shift of high-affinity site towards low-affinity. The affinity sites shifted towards high-affinity in LN rats. The number of low-affinity [H-3]bicuculline receptors decreased significantly in NDEA and PH whereas it increased in LN rats. GABA(A) receptor agonist, muscimol, dose dependently inhibited epidermal growth factor (EGF) induced DNA synthesis and enhanced the transforming growth factorbeta1 (TGF beta1) mediated DNA synthesis suppression in primary hepatocytecultures. Our results suggest that GABA(A) receptor act as an inhibitory signal for hepatic cell proliferation. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 13:30:52