Catalogo Articoli (Spogli Riviste)

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Titolo:
Helper T lymphocytes specific for cytokeratin 19 in patients with primary biliary cirrhosis
Autore:
Morishita, A; Murota, M; Fujita, J; Ohtsuki, Y; Nishioka, M;
Indirizzi:
Kagawa Med Univ, Dept Internal Med 3, Miki, Kagawa 7610793, Japan Kagawa Med Univ Miki Kagawa Japan 7610793 3, Miki, Kagawa 7610793, Japan Kagawa Med Univ, Dept Internal Med 1, Miki, Kagawa 7610793, Japan Kagawa Med Univ Miki Kagawa Japan 7610793 1, Miki, Kagawa 7610793, Japan Kochi Med Sch, Dept Pathol 2, Nankoku, Kochi 7838505, Japan Kochi Med SchNankoku Kochi Japan 7838505 , Nankoku, Kochi 7838505, Japan
Titolo Testata:
HEPATOLOGY RESEARCH
fascicolo: 2, volume: 21, anno: 2001,
pagine: 108 - 116
SICI:
1386-6346(200110)21:2<108:HTLSFC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTATIC LIVER-DISEASE; INTERFERON-GAMMA; CELL SUBSETS; EXPRESSION; PATTERNS; TH1; PATHOGENESIS; DETERMINANTS; RECOGNITION; HEPATOCYTES;
Keywords:
cytokeratin19; PBC; Th1; pathogenesis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
26
Recensione:
Indirizzi per estratti:
Indirizzo: Morishita, A Kagawa Med Univ, Dept Internal Med 3, 1750-1 Ikenobe, Miki, Kagawa 7610793, Japan Kagawa Med Univ 1750-1 Ikenobe Miki Kagawa Japan 7610793 apan
Citazione:
A. Morishita et al., "Helper T lymphocytes specific for cytokeratin 19 in patients with primary biliary cirrhosis", HEPATOL RES, 21(2), 2001, pp. 108-116

Abstract

We demonstrated the expression of cytokeratin 19 (CK19) in biliary cells in chronic non-suppurative destructive cholangitis (CNSDC) and hypothesized that this expression may have a correlation with the disease process in addition to cellular immunity which is believed to be involved in the pathogenesis of primary biliary cirrhosis (PBC). It is, therefore, important to clarify whether the destruction of bile ducts and biliary cells are caused by cellular immunity including helper T lymphocytes (Ths) and cytotoxic T lymphocytes (CTLs) specific for CK19. We examined the existence of helper T lymphocytes specific for CK19 in patients with PBC. As a result, the frequencies of responders having CK19 specific helper T lymphocytes and the stimulation index (SI) of the proliferative responses of peripheral blood mononuclear cells (PBMCs) were significantly higher and larger in patients with PBC compared with those of patients with chronic hepatitis C and normal subjects. The phenotype of proliferating PBMCs specific for CK19 were predominantly CD4+ Th1 cells. The Th1 response may help the induction of CTLs specific for CK19, and these CTLs could attack biliary cells. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 01:22:12