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Titolo:
A comparison of normal and leukemic stem cell biology in chronic myeloid leukemia
Autore:
Jorgensen, HG; Holyoake, TL;
Indirizzi:
Univ Glasgow, Glasgow Royal Infirm, Univ Hosp Trust, Dept Med,Acad Transfus Med Unit, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G31 2ER ow G31 2ER, Lanark, Scotland
Titolo Testata:
HEMATOLOGICAL ONCOLOGY
fascicolo: 3, volume: 19, anno: 2001,
pagine: 89 - 106
SICI:
0278-0232(200109)19:3<89:ACONAL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC MYELOGENOUS LEUKEMIA; TYROSINE KINASE INHIBITOR; HEMATOPOIETIC PROGENITOR CELLS; INTERFERON-ALPHA RESTORES; COLONY-STIMULATING FACTOR; ABL-POSITIVE CELLS; BCR-ABL; TELOMERE LENGTH; PHILADELPHIA-CHROMOSOME; BONE-MARROW;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
104
Recensione:
Indirizzi per estratti:
Indirizzo: Jorgensen, HG Univ Glasgow, Glasgow Royal Infirm, Univ Hosp Trust, Dept Med,Acad Transfus Med Unit, Glasgow G31 2ER, Lanark, Scotland Univ Glasgow Glasgow Lanark Scotland G31 2ER nark, Scotland
Citazione:
H.G. Jorgensen e T.L. Holyoake, "A comparison of normal and leukemic stem cell biology in chronic myeloid leukemia", HEMATOL ONC, 19(3), 2001, pp. 89-106

Abstract

Chronic Myeloid Leukemia (CML), a myeloproliferative disease of stem cell origin, is characterized by the presence of the Philadelphia (Ph) chromosome and the ber-abl oncogene. The BCR-ABL fusion gene product, thought to be causative in CML, has multiple effects on diverse cell functions such as growth, differentiation and turnover as well as adhesion and apoptosis. Persistent Ph-negative progenitors co-exist with leukemic cells, both in the marrow and blood of patients, in the early chronic phase or the disease. Despite accumulating knowledge or hemopoiesis and the disease process, CML remains incurable with conventional chemotherapy. Nonetheless, with the efficacyof the ABL tyrosine kinase inhibitor STI-571 (signal transduction inhibitor 571) as a novel therapy in CML recently being realized in clinical trials, it is therefore timely to review our current understanding of the cell biology of this fascinating disease. Copyright (C) 2001 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 11:05:42