Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Acquired haemophilia in association with organ-specific autoimmune disease
Autore:
Meiklejohn, DJ; Watson, HG;
Indirizzi:
Aberdeen Royal Infirm, Dept Haematol, Aberdeen AB25 2ZN, Scotland AberdeenRoyal Infirm Aberdeen Scotland AB25 2ZN deen AB25 2ZN, Scotland
Titolo Testata:
HAEMOPHILIA
fascicolo: 5, volume: 7, anno: 2001,
pagine: 523 - 525
SICI:
1351-8216(200109)7:5<523:AHIAWO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-VIII INHIBITORS; PORCINE FACTOR-VIII; HEMOPHILIA;
Keywords:
acquired haemophilia; autoimmune hypothroidism; haemolytic anaemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
8
Recensione:
Indirizzi per estratti:
Indirizzo: Meiklejohn, DJ Aberdeen Royal Infirm, Dept Haematol, Aberdeen AB25 2ZN, Scotland Aberdeen Royal Infirm Aberdeen Scotland AB25 2ZN Scotland
Citazione:
D.J. Meiklejohn e H.G. Watson, "Acquired haemophilia in association with organ-specific autoimmune disease", HAEMOPHILIA, 7(5), 2001, pp. 523-525

Abstract

A 72-year-old woman presented with multiple sites of soft tissue bleeding and a left ulnar neuropathy due to a compartment syndrome. There were also clinical signs of hypothyroidism. Factor VIII:C (FVIII) levels were 6% and a FVIII inhibitor with a titre of 9 Bethesda units was detected. She had biochemical evidence of hypothyroidism and high titres of antithyroid antibodies were detected. Two episodes of life- or limb-threatening haemorrhage were successfully treated with FEIBA. The inhibitor disappeared following 2 months of immunosuppression with oral cyclophosphamide and corticosteroids. She then developed autoimmune haemolytic anaemia, which responded to further immunosuppression with oral prednisolone. The association between acquired haemophilia and systemic autoimmune disorders such as systemic lupus erythematosis is well recognized, but our description of an association with organ-specific autoimmunity is more unusual.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:19:46