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Titolo:
The role of Epstein-Barr virus in systemic lupus erythematosus
Autore:
McClain, MT; Harley, JB; James, JA;
Indirizzi:
Oklahoma Med Res Fdn, Oklahoma City, OK 73104 USA Oklahoma Med Res Fdn Oklahoma City OK USA 73104 lahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Oklahoma City, OK USA Univ Oklahoma OklahomaCity OK USA , Hlth Sci Ctr, Oklahoma City, OK USA US Dept Vet Affairs Med Ctr, Oklahoma City, OK USA US Dept Vet Affairs MedCtr Oklahoma City OK USA , Oklahoma City, OK USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: E137 - E147
SICI:
1093-9946(200110)6:<E137:TROEVI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED AUTOIMMUNE RESPONSES; LYMPHOBLASTOID CELL-LINES; ENCODED NUCLEAR ANTIGEN; RHEUMATOID-ARTHRITIS; IMMUNE-RESPONSE; RISK-FACTORS; SM B/B'; EBNA-I; AUTOANTIBODIES; INFECTION;
Keywords:
systemic lupus erythematosus; viruses; Epstein-Barr virus; autoantibodies; autoimmunity; molecular mimicry; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: McClain, MT Oklahoma Med Res Fdn, 825 NE 13th St, Oklahoma City, OK 73104 USA Oklahoma Med Res Fdn 825 NE 13th St Oklahoma City OK USA 73104
Citazione:
M.T. McClain et al., "The role of Epstein-Barr virus in systemic lupus erythematosus", FRONT BIOSC, 6, 2001, pp. E137-E147

Abstract

Systemic lupus erythematosus (SLE) is a devastating autoimmune disease with no known cure. Lupus patients suffer from a myriad of clinical symptoms which variably include arthritis, pleuritis, pericarditis, vasculitis, and nephritis. The underlying mechanisms behind these clinical findings and the etiologic events preceding and causing disease onset, however, remain largely unknown. For many years, investigators have suspected that Epstein-Barr virus might somehow be involved in the etiology and/or pathogenesis of systemic lupus. Numerous studies have examined this possibility from various angles and have arrived at different conclusions. This work reviews these historical papers in the context of new results and presents a hypothetical role for this virus as an etiological environmental trigger for SLE.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 19:35:52