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Titolo:
Role of Muller cells in retinal degenerations
Autore:
Bringmann, A; Reichenbach, A;
Indirizzi:
Univ Leipzig, Paul Flechsig Inst Brain Res, D-04109 Leipzig, Germany Univ Leipzig Leipzig Germany D-04109 Brain Res, D-04109 Leipzig, Germany
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: E77 - E92
SICI:
1093-9946(200110)6:<E77:ROMCIR>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIAL GROWTH-FACTOR; FIBRILLARY ACIDIC PROTEIN; CILIARY NEUROTROPHIC FACTOR; OXYGEN-INDUCED RETINOPATHY; NITRIC-OXIDE SYNTHASE; INTERMEDIATE FILAMENT EXPRESSION; DEPENDENT GLUTAMATE TRANSPORT; RECTIFYING POTASSIUM CHANNEL; TRACTIONAL FORCE GENERATION; GLYCATION END-PRODUCTS;
Keywords:
Muller cell; glia; reactive gliosis; ionic homeostasis; transmitter recycling; trophic factors; proliferative retinopathies; neovascularization; retina degeneration; ischemia; hepatic retinopathy; retinoschisis; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
214
Recensione:
Indirizzi per estratti:
Indirizzo: Reichenbach, A Univ Leipzig, Paul Flechsig Inst Brain Res, Jahnallee 59, D-04109 Leipzig,Germany Univ Leipzig Jahnallee 59 Leipzig Germany D-04109 ,Germany
Citazione:
A. Bringmann e A. Reichenbach, "Role of Muller cells in retinal degenerations", FRONT BIOSC, 6, 2001, pp. E77-E92

Abstract

Muller (radial glial) cells span the entire thickness of the retina, and contact and ensheath every type of neuronal cell body and process. This morphological relationship is reflected by a multitude of functional interactions between retinal neurons and Muller cells, including extracellular ion homeostasis and glutamate recycling by Muller cells. Virtually every disease of the retina is associated with a reactive Muller cell gliosis. Muller cell gliosis may either support the survival of retinal neurons or accelerate the progress of neuronal degeneration. Muller cells are key mediators of nerve cell protection, especially via release of basic fibroblast growth factor, via uptake and degradation of the excitotoxin glutamate, and via secretion of the antioxidant glutathione. Neovascularization during hypoxic conditions is mediated by Muller cells via release of vascular endothelial growth factor and transforming growth factor beta or via direct contact to endothelial cells. Primary Muller cell insufficiency has been suggested to be the cause of different cases of retinal degeneration including hepatic and methanol-induced retinopathy and glaucoma. It is conceivable that, in the future, new therapeutic strategies may utilize Muller cells for, e.g., somaticgene therapy or transdifferentiation of retinal neurons from dedifferentiated Muller cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:01:00