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Titolo:
Intracellular signaling pathways: Nongenomic actions of estrogens and ligand-independent activation of estrogen receptors
Autore:
Coleman, KM; Smith, CL;
Indirizzi:
Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA Baylor Coll Med Houston TX USA 77030 Cellular Biol, Houston, TX 77030 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D1379 - D1391
SICI:
1093-9946(200110)6:<D1379:ISPNAO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE SYNTHASE; PROTEIN-KINASE-C; STEROID-HORMONE RECEPTORS; EPIDERMAL GROWTH-FACTOR; ESTRADIOL-INDUCED PHOSPHORYLATION; MEMBRANE-BINDING SITES; PITUITARY-TUMOR CELLS; BREAST-CANCER CELLS; PROGESTERONE-RECEPTOR; NUCLEAR RECEPTOR;
Keywords:
estrogen; cell signaling; transcription; nongenomic; steroid receptor; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
123
Recensione:
Indirizzi per estratti:
Indirizzo: Smith, CL Baylor Coll Med, Dept Mol & Cellular Biol, 1 Baylor Plaza, Houston, TX 77030 USA Baylor Coll Med 1 Baylor Plaza Houston TX USA 77030 TX 77030 USA
Citazione:
K.M. Coleman e C.L. Smith, "Intracellular signaling pathways: Nongenomic actions of estrogens and ligand-independent activation of estrogen receptors", FRONT BIOSC, 6, 2001, pp. D1379-D1391

Abstract

Recognition of the complexity of estrogen and estrogen receptor (ER) signaling has substantially increased in the last several years. In their genomic role, estrogens enter the cell and bind to ERs which are members of a superfamily of ligand-regulated transcription factors. However, estrogens alsoexert non-genomic effects that occur independently of gene transcription. Typically, these relatively rapid events are initiated at the plasma membrane, and result in the activation of intracellular signaling pathways. Regulation of ER transcriptional activity is also complex. Not only do ligands regulate ER-dependent gene expression, but this receptor in the apparent absence of its estrogenic ligand can also be transcriptionally activated by a variety of intracellular signaling pathways. Recent evidence also extends the effects of these signaling pathways to regulating the activity of coactivators, proteins which bind to the ER and amplify its transcriptional activity. Taken together, it is clear that estrogens, ERs and intracellular signaling pathways are intimately linked and this review will explore the relationship between these components of the estrogen-ER signal transduction process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:34:44