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Titolo:
Control of RNA polymerase II activity by dedicated CTD kinases and phosphatases
Autore:
Majello, B; Napolitano, G;
Indirizzi:
Univ Naples Federico II, Dept Genet & Mol Biol, I-80134 Naples, Italy UnivNaples Federico II Naples Italy I-80134 Biol, I-80134 Naples, Italy CNR, IIGB, I-80125 Naples, Italy CNR Naples Italy I-80125CNR, IIGB, I-80125 Naples, Italy
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D1358 - D1368
SICI:
1093-9946(200110)6:<D1358:CORPIA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CARBOXYL-TERMINAL DOMAIN; P-TEFB KINASE; NEGATIVE ELONGATION-FACTORS; VIRUS TYPE-1 TAT; HUMAN CYCLIN T1; TRANSCRIPTION ELONGATION; HIV-1 TAT; IN-VITRO; SACCHAROMYCES-CEREVISIAE; PROTEIN PHOSPHATASE;
Keywords:
P-TEFb/RNA polymerase II; CTD; cyclin-dependent kinase; FCP1 phosphatase; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
87
Recensione:
Indirizzi per estratti:
Indirizzo: Majello, B Univ Naples Federico II, Dept Genet & Mol Biol, Via Mezzocannone 8, I-80134 Naples, Italy Univ Naples Federico II Via Mezzocannone 8 Naples Italy I-80134
Citazione:
B. Majello e G. Napolitano, "Control of RNA polymerase II activity by dedicated CTD kinases and phosphatases", FRONT BIOSC, 6, 2001, pp. D1358-D1368

Abstract

The elongation phase of eukaryotic transcription by RNA polymerase II (RNAPII) is an important target for regulation of gene expression. An interplayof positive and negative elongation factors determines the elongation activity of RNAPII in different promoters. The phosphorylation status of the carboxyl-terminal-domain (CTD) of the larger subunit of RNAPII appears to be the regulatory focus of different factors regulating mRNA processivity. Theemerging model of the transcription cycle proposes that the phosphorylation state of the CTD is dynamic during elongation with different forms predominating at different stages of transcription. Shortly after initiation RNA polymerase II comes under the control of negative elongation factors and enters abortive elongation. Escape from the action of these negative controlsrequires the action of at least one positive elongation factor identified in the P-TEFb complex composed of the Cyclin-Dependent Kinase CDK9 and its regulatory subunit cyclin T. Finally, the requirement of CTD phosphatase activity, identified in the FCP1 protein, has been invoked as necessary to recycle the hypophosphorylated form of the RNA polymerase II competent to reinitiate the transcription cycle.

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Documento generato il 04/07/20 alle ore 20:09:51