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Titolo:
Mucin antibodies - New tools in diagnosis and therapy of cancer
Autore:
Wittel, UA; Goel, A; Varshney, GC; Batra, SK;
Indirizzi:
Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Dept Biochem & Mol Biol, Omaha, NE 68198 USA Univ Nebraska Omaha NE USA 68198 Biochem & Mol Biol, Omaha, NE 68198 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D1296 - D1310
SICI:
1093-9946(200110)6:<D1296:MA-NTI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
SINGLE-CHAIN FV; POLYMORPHIC EPITHELIAL MUCIN; 2ND-GENERATION MONOCLONAL-ANTIBODIES; HUMAN GASTRIC CARCINOMAS; ANTIGEN-BINDING PROTEIN; CELL LUNG-CANCER; OVARIAN-CANCER; SALIVARY MUCIN; BREAST-CANCER; BLADDER-CANCER;
Keywords:
mucins; monoclonal antibodies; recombinant antibodies; radioimmunotherapy; cancer; review;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
142
Recensione:
Indirizzi per estratti:
Indirizzo: Batra, SK Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Dept Biochem & Mol Biol, 600 S 42nd St,984525 Nebraska Med Ctr, Omaha, NE 68198 USA Univ Nebraska 600 S 42nd St,984525 Nebraska Med Ctr Omaha NE USA 68198
Citazione:
U.A. Wittel et al., "Mucin antibodies - New tools in diagnosis and therapy of cancer", FRONT BIOSC, 6, 2001, pp. D1296-D1310

Abstract

Many cancer and diseased cells are distinguished from their normal counterparts by an altered expression of cell-surface epitopes. One family of molecules that show altered expression on tumor cells is mucins (MUC). Unlike normal tissue where MUC exists as heavily glycosylated form, the disease- ortumor-associated MUC molecules are underglycosylated. Such underglycosylation of the core protein in cancer tissues exposes new epitopes on the cell surface that are unique to cancer tissues. Several monoclonal antibodies (Mabs) have been generated against these normal and tumor-associated mucins. Enzymatic fragments of Mabs like F(ab')(2) and Fab have shown improved clinical utility for diagnosis, imaging, and therapy of cancer. Genetic-engineering methods have been used to design antibody fragments exhibiting high functional affinity, good tumor localization, and rapid clearance from the blood stream thus minimizing radiation exposure to the normal tissues. Such recombinant fragments have shown encouraging results in preclinical studies using xenografted tumor bearing mice and present a whole new avenue for radioimmunotherapy and diagnosis of cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:49:14