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Titolo:
Normal respiratory mucosa, precursor lesions and lung carcinomas: Differential expression of human mucin genes
Autore:
Copin, MC; Buisine, MP; Devisme, L; Leroy, X; Escande, F; Gosselin, B; Aubert, JP; Porchet, N;
Indirizzi:
Univ Lille 2, Fac Med, CHRU Lille,Serv Anat & Cytol Pathol, Hop C Huriez,INSERM,U377,Lab Rech Gerard Biserte, Lille, France Univ Lille 2 Lille France M,U377,Lab Rech Gerard Biserte, Lille, France Univ Lille 2, Fac Med, CHRU Lille, Hop C Huriez,Lab Biochim & Biol Mol, Lille, France Univ Lille 2 Lille France Huriez,Lab Biochim & Biol Mol, Lille, France
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D1264 - D1275
SICI:
1093-9946(200110)6:<D1264:NRMPLA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GASTRIC CARCINOMAS; C-TERMINAL CLEAVAGE; BRONCHIOLOALVEOLAR CARCINOMA; CHROMOSOMAL LOCALIZATION; EPIDERMOID METAPLASIA; MONOCLONAL-ANTIBODIES; SURFACE EPITHELIUM; MOLECULAR-CLONING; PYLORIC MUCOSA; MESSENGER-RNA;
Keywords:
lung; bronchus; carcinoma; mucin gene; expression; in situ hybridization; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
81
Recensione:
Indirizzi per estratti:
Indirizzo: Copin, MC Ctr Hosp Reg & Univ Lille, Hop Calmette, Serv Anat & Cytol Pathol, Bd J Leclercq, F-59037 Lille, France Ctr Hosp Reg & Univ Lille Bd J Leclercq Lille France F-59037 ce
Citazione:
M.C. Copin et al., "Normal respiratory mucosa, precursor lesions and lung carcinomas: Differential expression of human mucin genes", FRONT BIOSC, 6, 2001, pp. D1264-D1275

Abstract

Mucins are glycoproteins synthesized by epithelial cells and thought to promote tumor-cell invasion. Eight human mucin genes have been well characterized: MUC2, MUC5AC, MUC5B, MUC6 map to 11p15.5 and encode secretory gel forming mucins while MUC1, MUC3, MUC4, MUC7 are scattered on different chromosomes and encode membrane-bound or secreted mucins. The expression pattern of the mucin genes is complex in normal airways involving six genes, mainly MUC5AC and MUC5B in mucus-producing cells and MUC4 in a wide array of epithelial cells. MUC5AC overexpression in metaplasia, dysplasia and normal epithelium adjacent to squamous cell carcinoma provides additional arguments for a mucous cell origin of preneoplastic squamous lesions. MUC5AC and MUC5B expression is related to mucus formation in adenocarcinomas. Mucinous bronchioloalveolar carcinoma (BAC) has a particular pattern of mucin gene expression indicating that it has sustained a well-differentiated phenotype similar to the goblet cell, correlated with distinctive features i.e. a noninvasive pattern and a better prognosis than nonBACs. MUC4 is the earlier mucin gene expressed in the foregut, before epithelial differentiation and is expressed independently of mucus secretion both in normal adult airways and carcinomas. These findings are in favor the histogenetic theory of non-small-cell carcinoma originating from a pluripotent mucous cell.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 08:54:24