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Titolo:
Regulation of mucin and glycoconjugate expression: From normal epithelium to gastric tumors
Autore:
de Bolos, C; Real, FX; Lopez-Ferrer, A;
Indirizzi:
Univ Pompeu Fabra, Inst Municipal Invest Med, Unitat Biol Cellular & Mol, Barcelona 08003, Spain Univ Pompeu Fabra Barcelona Spain 08003 ar & Mol, Barcelona 08003, Spain
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D1256 - D1263
SICI:
1093-9946(200110)6:<D1256:ROMAGE>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HELICOBACTER-PYLORI INFECTION; HUMAN GASTROINTESTINAL TISSUES; LEWIS ANTIGEN EXPRESSION; BLOOD-GROUP ANTIGENS; INTESTINAL METAPLASIA; GENE-EXPRESSION; HUMAN STOMACH; CARBOHYDRATE ANTIGENS; DISTINCT PATTERNS; CARCINOMA;
Keywords:
gastric mucins; fucosyltransferases; glycosylation; Helicobacter pylori; gastric carcinogenesis; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: de Bolos, C Univ Pompeu Fabra, Inst Municipal Invest Med, Unitat Biol Cellular & Mol, Dr Aiguader 80, Barcelona 08003, Spain Univ Pompeu Fabra Dr Aiguader 80 Barcelona Spain 08003 Spain
Citazione:
C. de Bolos et al., "Regulation of mucin and glycoconjugate expression: From normal epithelium to gastric tumors", FRONT BIOSC, 6, 2001, pp. D1256-D1263

Abstract

Gastric epithelium is protected by a mucus layer rich in MUC5AC and MUC6 mucins synthesised by the superficial epithelium and the glands, respectively. These cell populations also express specific fucosyltransferases that determine the glycosylation pattern of these gastric mucins. The maintenance of the structure and properties of the gastric mucus has been related to the degree of glycosylation and the oligomeric forms of the mucins. In gastric tumors, and in early preneoplastic lesions such as intestinal metaplasia,the glycosylation pattern detected in normal stomach is lost and, intestinal mucins, MUC2 and MUC4, can be ectopically detected in the gastric epithelium. These changes are biologically relevant because the binding of Helicobacter pylori to the gastric mucosa is mediated by blood group-related antigens. In vitro and animal models allowing the study of the gastric ecological niche and the requirements for its maintenance are essential for an understanding of the role of bacterial-mucosal interactions in pathological processes such as inflammation and cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 11:13:30