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Titolo:
Mucins of the human endocervix
Autore:
Gipson, IK;
Indirizzi:
Harvard Univ, Sch Med, Schepens Eye Res Inst, Boston, MA 02114 USA HarvardUniv Boston MA USA 02114 epens Eye Res Inst, Boston, MA 02114 USA Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA Harvard UnivBoston MA USA 02114 d, Dept Ophthalmol, Boston, MA 02114 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D1245 - D1255
SICI:
1093-9946(200110)6:<D1245:MOTHE>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
FEMALE REPRODUCTIVE-TRACT; HUMAN CERVICAL-MUCUS; ESTROGEN-RECEPTOR-ALPHA; MOLECULAR-CLONING; MENSTRUAL-CYCLE; GENOMIC ORGANIZATION; SIALOMUCIN COMPLEX; CHROMOSOMAL LOCALIZATION; RECURRENT MISCARRIAGE; SPERM PENETRABILITY;
Keywords:
MUC; mucin; mucin genes; endocervix; reproductive tract; MUC5B; MUC4; review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
90
Recensione:
Indirizzi per estratti:
Indirizzo: Gipson, IK Harvard Univ, Sch Med, Schepens Eye Res Inst, 20 Staniford St, Boston, MA 02114 USA Harvard Univ 20 Staniford St Boston MA USA 02114 , MA 02114 USA
Citazione:
I.K. Gipson, "Mucins of the human endocervix", FRONT BIOSC, 6, 2001, pp. D1245-D1255

Abstract

The physical character and amount of mucus secreted by the endocervix changes dramatically at midcycle to facilitate the reproductive process. Mucinsexpressed by the endocervical epithelium contribute to this all-important physiologic event. This review summarizes work from our laboratory demonstrating the mucin gene expression profile of cervical epithelium and mucin levels in cervical mucus through the menstrual cycle. mRNA levels of the gel-forming mucin MUC5B, the major gel-forming mucin expressed by the endocervical epithelium, peak before midcycle and the amount of MUC5B protein per unit total protein in cervical mucus peaks at midcycle. Message levels for MUC4, a major membrane-spanning mucin of the endocervix, peak at midcycle, but protein levels of MUC4 in human cervical mucus have not been measured. Message for each mucin diminishes dramatically as progesterone levels increase in the blood. These data suggest hormonal regulation of the two mucin genes in the endocervix, but there is no information on their regulation at the biosynthetic level via genomic hormone response elements. Perhaps, through its hydrophilicity, the MUC5B mucin holds water in place at the endocervical canal surface at midcycle, keeping the canal patent forsperm motility. A second potential role of the increased mucins at midcycle is to protect the cervix and uterus at the time when increased water is secreted into the cervical canal to facilitate sperm penetrance. Pathogens and other seminal fluid components may be excluded from entering the uterus by mucin trapping. Studies to determine the mechanism of hormonal regulation of mucins as well as the function of individual mucins are needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 03:06:46