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Titolo:
Receptor for AGE (RAGE) is a gene within the Major Histocompatibility Class III region: Implications for host response mechanisms in homeostasis and chronic disease
Autore:
Schmidt, AM; Stern, DM;
Indirizzi:
Columbia Univ Coll Phys & Surg, Dept Surg, New York, NY 10032 USA ColumbiaUniv Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Med, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Dept Physiol & Cellular Biophys, New York,NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 ew York,NY 10032 USA
Titolo Testata:
FRONTIERS IN BIOSCIENCE
, volume: 6, anno: 2001,
pagine: D1151 - D1160
SICI:
1093-9946(200110)6:<D1151:RFA(IA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCATION END-PRODUCTS; CELL-SURFACE RECEPTOR; BINDING-PROTEINS; NEURITE OUTGROWTH; SOLUBLE RECEPTOR; SIGNALING PATHWAYS; MAILLARD REACTION; APOLIPOPROTEIN-E; OXIDANT STRESS; MICE;
Keywords:
advanced glycation end products (AGE); amphoterin; diabetes; EN-RAGE; inflammation; receptor for advanced glycation end products (RAGE); review;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Schmidt, AM Columbia Univ Coll Phys & Surg, Dept Surg, 630 W 168th St,P&S 17-501, New York, NY 10032 USA Columbia Univ Coll Phys & Surg 630 W 168th St,P&S 17-501 New York NY USA 10032
Citazione:
A.M. Schmidt e D.M. Stern, "Receptor for AGE (RAGE) is a gene within the Major Histocompatibility Class III region: Implications for host response mechanisms in homeostasis and chronic disease", FRONT BIOSC, 6, 2001, pp. D1151-D1160

Abstract

Receptor for AGE (RAGE), a member of the immunoglobulin superfamily, was first identified as a specific cell surface interaction site for Advanced Glycation Endproducts, or AGEs. AGEs, the products of nonenzymatic glycation/oxidation of proteins/lipids, accumulate in natural aging and disorders such as diabetes, renal failure and amyloidoses. Interaction of AGEs with RAGEhas been linked to chronic inflammatory and vascular dysfunction that characterizes the chronic complications of these disorders. Recent studies haveindicated that RAGE is a multiligand receptor, serving as a specific cell surface, signal transducing receptor for amphoterin, a molecule with implications for neurite outgrowth in neuronal development and in tumor cell proliferation and spread. RAGE is also a receptor for amyloid-beta peptide, whose interaction with neuronal and microglial RAGE within the CNS is linked to sustained inflammation and neuronal toxicity and cell death. RAGE also serves as a signal-transducing receptor for EN-RAGEs, and related members of the S100/calgranulin family of proinflammatory cytokines; consequences of this interaction include initiation and propagation of inflammatory responses. Consistent with an important role for ligand-RAGE interaction in these settings, blockade of RAGE suppresses chronic cellular activation and dysfunction in murine models of diabetic complications, inflammation and tumor proliferation and metastasis. Taken together, an new paradigm is emerging which links RAGE, a gene encoded within the Major Histocompatibility Complex (MHC) Class III regions, to central host response mechanisms in homeostasis and chronic disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 08:58:10