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Titolo:
Drugs in postmortem adipose tissues: evidence of antemortem deposition
Autore:
Levisky, JA; Bowerman, DL; Jenkins, WW; Johnson, DG; Karch, SB;
Indirizzi:
El Paso Cty Coroners Off, Colorado Springs, CO 80906 USA El Paso Cty Coroners Off Colorado Springs CO USA 80906 ings, CO 80906 USA City & Cty San Francisco Hall Justice, San Francisco, CA 94103 USA City & Cty San Francisco Hall Justice San Francisco CA USA 94103 4103 USA
Titolo Testata:
FORENSIC SCIENCE INTERNATIONAL
fascicolo: 3, volume: 121, anno: 2001,
pagine: 157 - 160
SICI:
0379-0738(20011001)121:3<157:DIPATE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALTERNATIVE MATRICES; COCAINE; SWEAT; CODEINE;
Keywords:
adipose tissue; postmortem redistribution; illicit drugs; sweat patch;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
9
Recensione:
Indirizzi per estratti:
Indirizzo: Levisky, JA El Paso Cty Coroners Off, 2743 E Las Vegas St, Colorado Springs, CO 80906 USA El Paso Cty Coroners Off 2743 E Las Vegas St Colorado Springs CO USA 80906
Citazione:
J.A. Levisky et al., "Drugs in postmortem adipose tissues: evidence of antemortem deposition", FOREN SCI I, 121(3), 2001, pp. 157-160

Abstract

Introduction: Drug concentration measured in postmortem adipose tissue mayor may not reflect antemortem concentration. To examine the possibility ofwhether the presence of basic drugs in adipose tissue is the result of postmortem change, we examined: tissues with and without livor mortis, concentration gradients within the adipose layer, and the stability of drug concentrations during the postmortem period. Case Reports: Five drug-related deaths with case histories, and analytical data are presented. Adipose tissues with and without livor mortis front the thigh area of the same decedent were analyzed for cocaine. The cocaine concentration of the tissue exhibiting 4+ livor was equivalent to the concentration observed in tissue without livor. Analyses of cross sections of adipose tissues containing cocaine and methamphetamine disclosed that drug concentrations were equally distributed throughout the layer, from just beneath the dermis to directly above the muscle. When morphine and temazepam concentrations were measured in adipose tissues collected from similar sites. but at different times, from the same cadaver, they remained essentially the same over 3 days (approximately 80 h). Conclusions: Since concentrations were the same in areas with and withoutlivor mortis, the possibility of redistribution into adipose from blood orvascular channels is eliminated. The absence of a concentration gradient within the adipose layer rules out diffusion or permeation from muscle into the adipose layer, and the failure of morphine or temazepam concentration to change over time indicates that drugs in the adipose tissue are stable during the postmortem interval. Our findings support the notion that drugs identified in postmortem adipose tissue are there because of antemortem deposition and not because of any postmortem change or event. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 05:39:43