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Titolo:
Rationale for the existence of additional adipostatic hormones
Autore:
Fruhbeck, G; Gomez-Ambrosi, J;
Indirizzi:
Univ Navarra Clin, Dept Endocrinol, Pamplona 31008, Spain Univ Navarra Clin Pamplona Spain 31008 Endocrinol, Pamplona 31008, Spain Univ Navarra, Metab Res Lab, E-31080 Pamplona, Spain Univ Navarra Pamplona Spain E-31080 tab Res Lab, E-31080 Pamplona, Spain
Titolo Testata:
FASEB JOURNAL
fascicolo: 11, volume: 15, anno: 2001,
pagine: 1996 - 2006
SICI:
0892-6638(200109)15:11<1996:RFTEOA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIABETES-OBESITY SYNDROMES; BODY-WEIGHT REGULATION; REPRODUCTIVE FUNCTION; LEPTIN RECEPTOR; ENERGY-BALANCE; FEMALE MICE; OB/OB MICE; RECOMBINANT LEPTIN; FOOD RESTRICTION; TRANSGENIC MICE;
Keywords:
leptin; parabiosis; lipostatic factor; obesity; energy balance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Fruhbeck, G Univ Navarra Clin, Dept Endocrinol, Pamplona 31008, Spain UnivNavarra Clin Pamplona Spain 31008 Pamplona 31008, Spain
Citazione:
G. Fruhbeck e J. Gomez-Ambrosi, "Rationale for the existence of additional adipostatic hormones", FASEB J, 15(11), 2001, pp. 1996-2006

Abstract

Parabiosis studies with obese rodents demonstrated that circulating factors are involved in the long-term control of food intake and energy balance. More than 40 years ago it was hypothesized that rats made obese by hypothalamic or dietary means, as well as genetically obese fa/fa rats and db/db mice, produce a circulating factor that either inhibits food intake or acts metabolically to reduce the fat content of non-obese ad libitum-fed partners. However, none of these obese rodents showed a significant change in weight when parabiosed to a normal animal. It was therefore postulated that these obese rodents produced a circulating lipostatic factor but were unable torespond to it. In contrast, genetically obese ob/ob mice were thought to be deficient in the circulating signal, as they lost weight when parabiosed to lean or obese db/db mice. The discovery of leptin suggested that the circulating lipostatic signal had been identified. However, a closer look at the outcome of the parabiotic studies reveals that leptin alone does not explain all of the findings of the parabiotic experiments. Another (or more than one) as yet unidentified factor(s) may be involved in energy balance regulation. The evidence for the existence of further leptin-like hormones comes from observations in which the direct effect of leptin has been eliminated or can be excluded.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 12:41:25