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Titolo:
Macrophages require different nucleoside transport systems for proliferation and activation
Autore:
Soler, C; Garcia-Manteiga, J; Valdes, R; Xaus, J; Comalda, M; Casado, FJ; Pastor-Anglada, M; Celada, A; Felipe, A;
Indirizzi:
Univ Barcelona, Dept Bioquim & Biol Mol, Lab Fisiol Mol, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 iol Mol, E-08028 Barcelona, Spain Univ Barcelona, Dept Fisiol Biol Macrofag, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 acrofag, E-08028 Barcelona, Spain Univ Barcelona, Fdn August Pi I Sunyer, E-08028 Barcelona, Spain Univ Barcelona Barcelona Spain E-08028 Sunyer, E-08028 Barcelona, Spain
Titolo Testata:
FASEB JOURNAL
fascicolo: 11, volume: 15, anno: 2001,
pagine: 1979 - 1988
SICI:
0892-6638(200109)15:11<1979:MRDNTS>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE PHOSPHATASE-1; RAT-LIVER; MOLECULAR-BIOLOGY; INTERFERON-GAMMA; B-LYMPHOCYTES; CELLS; EXPRESSION; RECEPTOR; MOUSE; LIPOPOLYSACCHARIDE;
Keywords:
nucleoside uptake; interferon gamma; macrophage colony-stimulating factor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Felipe, A Univ Barcelona, Dept Bioquim & Biol Mol, Lab Fisiol Mol, Avda Diagonal 645, E-08028 Barcelona, Spain Univ Barcelona Avda Diagonal 645 Barcelona Spain E-08028 Spain
Citazione:
C. Soler et al., "Macrophages require different nucleoside transport systems for proliferation and activation", FASEB J, 15(11), 2001, pp. 1979-1988

Abstract

proliferation and activation, we studied the regulation of the nucleoside transport systems. In murine bone marrow-derived macrophages, the nucleosides required for DNA and RNA synthesis are recruited from the extracellular medium. M-CSF induced macrophage proliferation and DNA and RNA synthesis, whereas interferon gamma (IFN-gamma) led to activation, blocked proliferation, and induced only RNA synthesis. Macrophages express at least the concentrative systems N1 and N2 (CNT2 and CNT1 genes, respectively) and the equilibrative systems es and ei (ENT1 and ENT2 genes, respectively). Incubation with M-CSF only up-regulated the equilibrative system es. Inhibition of thistransport system blocked M-CSF-dependent proliferation. Treatment with IFN-gamma only induced the concentrative N1 and N2 systems. IFN-gamma also down-regulated the increased expression of the es equilibrative system inducedby M-CSF. Thus, macrophage proliferation and activation require selective regulation of nucleoside transporters and may respond to specific requirements for DNA and RNA synthesis. This report also shows that the nucleoside transporters are critical for macrophage proliferation and activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 03:57:00