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Titolo:
High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock
Autore:
Cockerill, GW; McDonald, MC; Mota-Filipe, H; Cuzzocrea, S; Miller, NE; Thiemermann, C;
Indirizzi:
Univ London Queen Mary & Westfield Coll, St Bartholomews & Royal London SMD, London EC1M 6BQ, England Univ London Queen Mary & Westfield Coll London England EC1M 6BQ England Univ Messina, Sch Med, Inst Pharmacol, I-98123 Messina, Italy Univ Messina Messina Italy I-98123 nst Pharmacol, I-98123 Messina, Italy
Titolo Testata:
FASEB JOURNAL
fascicolo: 11, volume: 15, anno: 2001,
pagine: 1941 - 1952
SICI:
0892-6638(200109)15:11<1941:HDLROI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MACROPHAGE INFLAMMATORY PROTEIN-2; APOLIPOPROTEIN-A-I; ISCHEMIA-REPERFUSION INJURY; CYTOKINE-INDUCED EXPRESSION; TUMOR-NECROSIS-FACTOR; ADHESION MOLECULES; LUNG INJURY; ALVEOLAR MACROPHAGES; SELECTIN EXPRESSION; ENDOTHELIAL-CELLS;
Keywords:
cytokines; chemokines; intercellular adhesion molecule 1; interleukin 8; multiple organ failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Cockerill, GW Univ London Queen Mary & Westfield Coll, St Bartholomews & Royal London SMD, London EC1M 6BQ, England Univ London Queen Mary & Westfield Coll London England EC1M 6BQ
Citazione:
G.W. Cockerill et al., "High density lipoproteins reduce organ injury and organ dysfunction in a rat model of hemorrhagic shock", FASEB J, 15(11), 2001, pp. 1941-1952

Abstract

High density lipoproteins (HDLs) inhibit the cytokine-induced expression of endothelial cell adhesion molecules both in vitro and in vivo. We examined the ability of HDLs to mediate a functional anti-inflammatory effect by measuring their ability to prevent neutrophil adhesion and transmigration invitro. Treatment of human endothelial cell cultures with physiologic concentrations of HDLs inhibited neutrophil binding by 68 +/-5.9% (mean and SE, n=6, P<0.05) and neutrophil transmigration by 48.7<plus/minus>6.7% (n=8, P<0.05). We then examined the effect of HDLs on inflammatory infiltration andsubsequent multiple organ dysfunction syndrome (MODS), associated with trauma in a rat model of hemorrhagic shock. Rats given human HDLs (80 mg apo A-I/kg, i.v.) 90 min after hemorrhage (which reduced mean arterial pressure to 50 mmHg) and 1 min before resuscitation showed attenuation of the increases in the serum levels of markers of MODS normally observed in this model. Severe disruption of the architecture of tissues and the extensive cellular infiltration into those tissues were also largely inhibited in animals that received HDLs. Human HDLs attenuate the MODS associated with ischemia and reperfusion injury after hemorrhagic shock in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 07:54:22