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Titolo:
beta-Adrenergic receptors (bAR) regulate cardiomyocyte proliferation during early postnatal life
Autore:
Tseng, YT; Kopel, R; Stabila, JP; McGonnigal, BG; Nguyen, TT; Gruppuso, PA; Padbury, JF;
Indirizzi:
Women & Infants Hosp Rhode Isl, Rhode Isl Hosp, Brown Med Sch, Dept Pediat, Providence, RI 02905 USA Women & Infants Hosp Rhode Isl Providence RI USA 02905 ence, RI 02905 USA
Titolo Testata:
FASEB JOURNAL
fascicolo: 11, volume: 15, anno: 2001,
pagine: 1921 - 1926
SICI:
0892-6638(200109)15:11<1921:BR(RCP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN-KINASE PATHWAY; NEONATAL RAT; TARGETED DISRUPTION; CARDIAC GROWTH; HEART; ADRENOCEPTOR; STIMULATION; ACTIVATION; AGONISTS; CASCADE;
Keywords:
MAPK; p70 S6K; propranolol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Tseng, YT Women & Infants Hosp Rhode Isl, Rhode Isl Hosp, Brown Med Sch, Dept Pediat, 101 Dudley St, Providence, RI 02905 USA Women & Infants Hosp Rhode Isl 101 Dudley St Providence RI USA 02905
Citazione:
Y.T. Tseng et al., "beta-Adrenergic receptors (bAR) regulate cardiomyocyte proliferation during early postnatal life", FASEB J, 15(11), 2001, pp. 1921-1926

Abstract

Cardiomyocyte development switches from hyperplasmic to hypertrophic growth between postnatal days 3 and 4 in rats. The mechanisms responsible for this transition have been controversial. beta -Adrenergic receptor (beta AR) activation of mitogenic responses in vitro has been reported. We hypothesized that tonic activation of the beta AR signaling regulates cell division in neonatal cardiomyocytes via effects on signaling kinases known to be important in cell cycle regulation. The purpose of the current study was to elucidate the roles of beta AR in rat cardiomyocyte growth in vivo. We demonstrated that beta AR blockade induced a significant reduction in cardiomyocyte proliferation as measured by the BrdU labeling index. Blockade of beta ARdid not affect p38 or p44/42 MAPK activities. We further demonstrated thatbeta AR blockade induced a prompt deactivation of the p70 ribosomal protein S6 kinase (p70 S6K). To confirm these results, we measured p70 S6K activity directly. Basal activity of p70 S6K in neonatal cardiomyocytes was fourfold higher than that of insulin-treated adult rat liver. The activity of p70 S6K was reduced by 60% within 1 min after beta AR blockade. We conclude that the beta AR are involved in regulation of neonatal cardiomyocyte proliferation and that this mitogenic control may be mediated via the p70 S6K pathway.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:58:56