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Titolo:
Antisense oligonucleotides as drugs for HIV treatment
Autore:
Galderisi, U; Cipollaro, M; Cascino, A;
Indirizzi:
Univ Naples 2, CRISCEB, Dept Expt Med, Sect Mol Biol & Biotechnol, Naples,Italy Univ Naples 2 Naples Italy ed, Sect Mol Biol & Biotechnol, Naples,Italy
Titolo Testata:
EXPERT OPINION ON THERAPEUTIC PATENTS
fascicolo: 10, volume: 11, anno: 2001,
pagine: 1605 - 1611
SICI:
1354-3776(200110)11:10<1605:AOADFH>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; PHOSPHOROTHIOATE OLIGONUCLEOTIDES; CULTURED-CELLS; INHIBITION; OLIGODEOXYNUCLEOTIDES; PHARMACOKINETICS; REPLICATION; THERAPY; RATS; DISPOSITION;
Keywords:
antisense; clinical patents; HIV; oligonucleotides; phosphorothioated oligonucleotides;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Galderisi, U Univ Naples 2, CRISCEB, Dept Expt Med, Sect Mol Biol & Biotechnol, Naples,Italy Univ Naples 2 Naples Italy Biol & Biotechnol, Naples,Italy
Citazione:
U. Galderisi et al., "Antisense oligonucleotides as drugs for HIV treatment", EXPERT OP T, 11(10), 2001, pp. 1605-1611

Abstract

Nowadays, several million people suffer from AIDS and more than 100 million people are forecasted to be infected with HIV. Among new drugs used to stop HIV virus infection, antisense oligodeoxynucleotides (ODNs) are under investigation and several biotechnology companies are currently developing antisense drugs. Antisense ODNs are short stretches of DNA complementary to atarget mRNA. The ODNs selectively hybridise to their complementary RNA by Watson-Crick base pairing rules. In theory, the use of antisense ODNs provides a method to specifically inhibit the intracellular expression of any disorder. This review describes some of the clinical patents in the field of HIV treatments by antisense ODNs. These prior attempts at targeting HIV have largely focused on the nature of the chemical modification used in the ODN moiety. Although each of the described inventions have reported some degree of success in inhibiting some function of the virus, a general therapeutic scheme to target HIV has not yet been found.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 08:42:27