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Titolo:
Human alveolar long-term clearance of ferromagnetic iron oxide microparticles in healthy and diseased subjects
Autore:
Moller, W; Barth, W; Kohlhaufl, M; Haussinger, K; Stahlhofen, W; Heyder, J;
Indirizzi:
Inst Inhalat Biol, GSF Natl Res Ctr Environm & Hlth, Clin Res Grp AerosolsMed, D-82131 Gauting, Germany Inst Inhalat Biol Gauting Germany D-82131 sMed, D-82131 Gauting, Germany GSI Darmstadt, Natl Res Ctr Heavy Ions, D-6100 Darmstadt, Germany GSI Darmstadt Darmstadt Germany D-6100 y Ions, D-6100 Darmstadt, Germany
Titolo Testata:
EXPERIMENTAL LUNG RESEARCH
fascicolo: 7, volume: 27, anno: 2001,
pagine: 547 - 568
SICI:
0190-2148(200110/11)27:7<547:HALCOF>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC PULMONARY FIBROSIS; LUNG CLEARANCE; INTRAPHAGOSOMAL PH; PARTICLES; MACROPHAGES; RATS; SARCOIDOSIS; INHALATION; STATEMENT; EXPOSURE;
Keywords:
alveolar clearance; chronic obstructive bronchitis (COB); cigarette smoke; idiopathic pulmonary fibrosis; iron oxide microparticles; sarcoidosis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
45
Recensione:
Indirizzi per estratti:
Indirizzo: Moller, W Inst Inhalat Biol, GSF Natl Res Ctr Environm & Hlth, Clin Res Grp AerosolsMed, D-82131 Gauting, Germany Inst Inhalat Biol Gauting GermanyD-82131 131 Gauting, Germany
Citazione:
W. Moller et al., "Human alveolar long-term clearance of ferromagnetic iron oxide microparticles in healthy and diseased subjects", EXP LUNG R, 27(7), 2001, pp. 547-568

Abstract

Monodisperse ferrimagnetic microparticles (Fe3O4) with 1.3 mum geometric diameter were inhaled to study alveolar long-term clearance in healthy and diseased human subjects. Nineteen younger(age 20 to 39 years) and 20 older (age 40 to 65 years) healthy volunteers participated in tilt, Study as well as 15 patients with sarcoidosis (SAR), 12 patients with idiopathic pulmonary fibrosis (IPF), and 15 patients with chronic obstructive bronchitis (COB). In each group the subjects were divided into never smokers (NS) and active smokers (S). Clearance was measured by magnetopneumography (MPG) for 300 days after inhalation. In COB, 50% of the deposited particles were removed from the lungs after 2 days, indicating high bronchial deposits due to bronchial obstructions. In healthy NS, only 10% of the particles were removed after 2 days and cigarette smoking enhanced the fraction of fast-cleared particles. In subjects who smoked, slow clearance was significantly impaired (P < .02). Clearance half-lives (in days) for younger, healthy, NS were 124 /- 66 (mean SD) compared to 220 +/- 74 for S. Similarly for older subjects, the times were 162 +/- 120 for NS and 459 +/- 334 for S. The impairment of alveolar clearance due to cigarette smoking increases by 5.7 +/- 1.3 days/pack-year (P < .01). Alveolar clearance was impaired in SAR and in IPF; half-lives were 275 +/- 109 days (P < .05) and 756 +/- 345 days (P < .02), respectively, compared to healthy MS. Most COB patients were ex-smokers, their long-term clearance was 240 +/- 74 days, which is more than healthy NS (P< .01), but less than healthy S and might indicate a recovery of alveolar clearance. In view of studies using totally inert particles like Teflon, weconclude that the lung clearance measured with iron oxide tracer particlesprimarily reflects clearance by intraphagosomal particle dissolution within alveolar macrophages, which is impaired by cigarette smoke consumption and in patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 11:57:07