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Titolo:
Redundant function of macrophage inflammatory protein-2 and KC in tumor necrosis factor-alpha-induced extravasation of neutrophils in vivo
Autore:
Zhang, XW; Wang, YS; Liu, Q; Thorlacius, H;
Indirizzi:
Lund Univ, Dept Surg, Malmo Univ Hosp, S-20502 Malmo, Sweden Lund Univ Malmo Sweden S-20502 g, Malmo Univ Hosp, S-20502 Malmo, Sweden
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 427, anno: 2001,
pagine: 277 - 283
SICI:
0014-2999(20010921)427:3<277:RFOMIP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED LUNG INJURY; C-X-C; TNF-ALPHA; IN-VIVO; BACTERIAL CLEARANCE; ENDOTHELIAL-CELLS; RECRUITMENT; CHEMOKINES; ADHESION; IL-8;
Keywords:
chemokine; inflammation; intravital microscopy; leukocyte; microcirculation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Thorlacius, H Lund Univ, Dept Surg, Malmo Univ Hosp, S-20502 Malmo, SwedenLund Univ Malmo Sweden S-20502 Hosp, S-20502 Malmo, Sweden
Citazione:
X.W. Zhang et al., "Redundant function of macrophage inflammatory protein-2 and KC in tumor necrosis factor-alpha-induced extravasation of neutrophils in vivo", EUR J PHARM, 427(3), 2001, pp. 277-283

Abstract

Tumor necrosis factor-alpha (TNF-alpha) stimulates the expression CXC chemokines, i.e. macrophage inflammatory protein-2 (MIP-2) and cytokine-inducedneutrophil chemoattractant (KC), and neutrophil extravasation. However, the individual role of MIP-2 and KC in the recruitment process of neutrophilsin vivo remains elusive. By use of intravital microscopy in the mouse cremaster muscle, we analyzed the effect of specific inhibition of CXC chemokines, alone and together, on TNF-alpha -induced leukocyte rolling, firm adhesion and recruitment. After stimulation with TNF-alpha, the mRNA levels of both MIP-2 and KC were increased. Notably, separate administration of antibodies directed against MIP-2 and KC had no effect on TNF-alpha -induced neutrophil extravasation. In contrast, combined injection of anti-MIP-2 and anti-KC antibodies markedly inhibited extravascular migration of neutrophils. Moreover, MIP-2 and KC dose-dependently increased neutrophil recruitment, however, no synergistic effect of combined stimulation with MIP-2 and KC on the neutrophil response was found. Taken to-ether, these data suggest that MIP-2 and KC are functionally redundant in TNF-alpha -induced neutrophil accumulation and that neutralization of both MIP-2 and KC may be necessary inorder to reduce accumulation of neutrophils in cytokine-activated tissues. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:19:31