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Titolo:
MS-377, a novel selective sigma(1) receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain
Autore:
Takahashi, S; Horikomi, K; Kato, T;
Indirizzi:
Nihon Schering KK, Drug Discovery Inst, Chiba 2970017, Japan Nihon Schering KK Chiba Japan 2970017 scovery Inst, Chiba 2970017, Japan Yokohama City Univ, Grad Sch Integrated Sci, Lab Mol Recognit, Kanazawa Ku, Yokohama, Kanagawa 2360027, Japan Yokohama City Univ Yokohama Kanagawa Japan 2360027 anagawa 2360027, Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 3, volume: 427, anno: 2001,
pagine: 211 - 219
SICI:
0014-2999(20010921)427:3<211:MANSSR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEDIAL PREFRONTAL CORTEX; IN-VIVO MICRODIALYSIS; NUCLEUS-ACCUMBENS; ANTIPSYCHOTIC-DRUGS; EXTRACELLULAR CONCENTRATION; PREPULSE INHIBITION; INDUCED DISRUPTION; CORTICAL DOPAMINE; ACOUSTIC STARTLE; CLOZAPINE;
Keywords:
sigma(1) receptor ligand; MS-377; phencyclidine; microdialysis, in vivo; prefrontal cortex, medial;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Takahashi, S Nihon Schering KK, Drug Discovery Inst, 1900-1 Togo, Chiba 2970017, Japan Nihon Schering KK 1900-1 Togo Chiba Japan 2970017 017, Japan
Citazione:
S. Takahashi et al., "MS-377, a novel selective sigma(1) receptor ligand, reverses phencyclidine-induced release of dopamine and serotonin in rat brain", EUR J PHARM, 427(3), 2001, pp. 211-219

Abstract

A novel selective g, receptor ligand, (R)-(+)-1-(4-chlorophenyl)-3-[4-(2-methoxyethyl)piperazin-1-yl]methyl-2-pyrrolidinone L-tartrate (MS-377), inhibits phencyclidine (1-(1-phenylcyclohexyl)piperidine; PCP)-induced behaviors in animal models. In this study, we measured extracellular dopamine and serotonin levels in the rat brain after treatment with MS-377 alone, using in vivo microdialysis. We also examined the effects of MS-377 on extracellular dopamine and serotonin levels in the rat medial prefrontal cortex after treatment with PCP. MS-377 itself had no significant effects on dopamine release in the striatum (10 mg/kg, p.o.) not on dopamine or serotonin releasein the medial prefrontal cortex (1 and 10 mg/kg, p.o.). PCP (3 mg/kg, i.p.) markedly increased dopamine and serotonin release in the medial prefrontal cortex. MS-377 (I mg/kg,, p.o.), when administered 60 min prior to PCP, significantly attenuated this effect of PCP. These results suggest that the inhibitory effects of MS-377 on PCP-induced behaviors are partly mediated by inhibition of the increase in dopamine and serotonin release in the rat medial prefrontal cortex caused by PCP. (C) 2001 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 07:28:58