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Titolo:
Animal and culture models of glaucoma for studying neuroprotection
Autore:
Levin, LA;
Indirizzi:
Univ Wisconsin, Sch Med, Dept Ophthalmol & Visual Sci, Madison, WI 53792 USA Univ Wisconsin Madison WI USA 53792 l & Visual Sci, Madison, WI 53792 USA
Titolo Testata:
EUROPEAN JOURNAL OF OPHTHALMOLOGY
, volume: 11, anno: 2001, supplemento:, 2
pagine: S23 - S29
SICI:
1120-6721(200107/09)11:<S23:AACMOG>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; MONOSODIUM-L-GLUTAMATE; OPTIC-NERVE ISCHEMIA; IRIS ATROPHY; DBA/2J MICE; RAT; DEGENERATION; THERAPY; INJURY; DEATH;
Keywords:
neuroprotection; glaucoma; optic neuropathy; animal models; retinal ganglion cell;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Levin, LA Univ Wisconsin, Sch Med, Dept Ophthalmol & Visual Sci, 600 Highland Ave, Madison, WI 53792 USA Univ Wisconsin 600 Highland Ave Madison WI USA 53792 I 53792 USA
Citazione:
L.A. Levin, "Animal and culture models of glaucoma for studying neuroprotection", EUR J OPTHA, 11, 2001, pp. S23-S29

Abstract

PURPOSE. Neuroprotection aims to treat nervous system disease by maintaining the health and function of neurons. The final proof of the neuroprotective strategy relies on randomized, controlled clinical trials, but the choice of which agents to study for these trials depends on studies in the laboratory using culture and animal models. Most culture models for studying ocular neuroprotection use retinal cells, and a range of mechanisms can be studied in culture, e.g. axotomy and serum or growth factor deprivation. METHODS. A variety of animal models are available for studying neuroprotection as possible therapy for glaucomatous optic neuropathy. Those most closely related to glaucoma are probably associated with moderate elevation of the intraocular pressure to levels similar to those seen in patients with untreated glaucomatous optic. neuropathy. CONCLUSIONS. Care should be taken when applying the results of these models to humans and there is no single criterion for deciding which culture or animal model is most relevant to the clinical situation. The most importantfeature is whether the model's results correlate with clinical results, and this information will only become available over time, as randomized clinical trials are completed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 01:10:15