Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Apoptosis and anti-apoptosis signalling in glaucomatous retinopathy
Autore:
Tatton, WG; Chalmers-Redman, RME; Tatton, NA;
Indirizzi:
CUNY, Mt Sinai Med Ctr, Dept Neurol, New York, NY 10029 USA CUNY New YorkNY USA 10029 i Med Ctr, Dept Neurol, New York, NY 10029 USA CUNY, Mt Sinai Med Ctr, Dept Ophthalmol, New York, NY 10029 USA CUNY New York NY USA 10029 d Ctr, Dept Ophthalmol, New York, NY 10029 USA
Titolo Testata:
EUROPEAN JOURNAL OF OPHTHALMOLOGY
, volume: 11, anno: 2001, supplemento:, 2
pagine: S12 - S22
SICI:
1120-6721(200107/09)11:<S12:AAASIG>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL GANGLION-CELLS; FIBROBLAST-GROWTH-FACTOR; CYTOCHROME-C RELEASE; MITOCHONDRIAL PERMEABILITY TRANSITION; OPTIC-NERVE HEAD; ADENINE-NUCLEOTIDE TRANSLOCATOR; ELEVATED INTRAOCULAR-PRESSURE; ACTIVATED PROTEIN-KINASE; NITRIC-OXIDE SYNTHASE-2; INDUCED NEURONAL DEATH;
Keywords:
glaucoma; apoptosis; mitochondria;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
120
Recensione:
Indirizzi per estratti:
Indirizzo: Tatton, WG CUNY, Mt Sinai Med Ctr, Dept Neurol, Annenberg 14-70,1 Gustave L Levy Pl, New York, NY 10029 USA CUNY Annenberg 14-70,1 Gustave L Levy Pl New York NY USA 10029
Citazione:
W.G. Tatton et al., "Apoptosis and anti-apoptosis signalling in glaucomatous retinopathy", EUR J OPTHA, 11, 2001, pp. S12-S22

Abstract

PURPOSE. Recent studies in the post-mortem human retina have suggested that apoptosis contributes to retinal ganglion cell (RGC) loss in glaucoma. Ifapoptosis contributes significantly to glaucomatous RGC loss, and if the specific apoptosis signalling pathways for glaucomatous apoptosis can be determined, agents that interrupt or oppose the signalling have the potential to slow the progression of glaucoma. METHODS. Recent data in animal models indicate that mitochondrially-dependent apoptosis contributes to RGC loss in glaucoma. Mitochondrially-dependent apoptosis involves proteins like BAX that increase mitochondrial membranepermeability and promote apoptosis and proteins like BCL-2 that decrease mitochondrial membrane permeability and reduce apoptosis. New protein synthesis induced by the alpha-2 agonist, brimonidine, prevents decreases in the levels of BCL-2 and thereby reduces mitochondrially-dependent apoptosis. CONCLUSIONS. Brimonidine appears to maintain BCL-2 levels by supporting the activity of an intrinsic anti-apoptosis signalling system that involves phosphorylation of protein kinase B. Phosphorylated protein kinase B appearsto counteract the apoptosis signalling mechanisms which operate in glaucomatous retina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 22:54:33