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Titolo:
Infants differ from teenagers: use of non-invasive tests for detection of Helicobacter pylori infection in children
Autore:
Koletzko, S; Feydt-Schmidt, A;
Indirizzi:
Univ Munich, Dr v Haunersches Kinderspital, Kinderklin & Kinderpoliklin, D-80336 Munich, Germany Univ Munich Munich Germany D-80336 nderpoliklin, D-80336 Munich, Germany
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 9, volume: 13, anno: 2001,
pagine: 1047 - 1052
SICI:
0954-691X(200109)13:9<1047:IDFTUO>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
UREA BREATH TEST; ANTIGEN ENZYME-IMMUNOASSAY; STOOL SPECIMENS; PEDIATRIC-PATIENTS; DIAGNOSIS; ERADICATION; THERAPY; SERODIAGNOSIS; MULTICENTER; ACQUISITION;
Keywords:
adolescents; C-13-urea breath test; children; diagnostic tests; Helicobacter pylori; infants; serology; stool test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Koletzko, S Univ Munich, Dr v Haunersches Kinderspital, Kinderklin & Kinderpoliklin, Pettenkoferstr 8A, D-80336 Munich, Germany Univ Munich Pettenkoferstr 8A Munich Germany D-80336 Germany
Citazione:
S. Koletzko e A. Feydt-Schmidt, "Infants differ from teenagers: use of non-invasive tests for detection of Helicobacter pylori infection in children", EUR J GASTR, 13(9), 2001, pp. 1047-1052

Abstract

Reliable non-invasive tests that are feasible in early childhood are essential to the study of transmission of Helicobacter pylori, since most individuals get infected during the first years of life. New tests are validated by comparison with a 'gold standard', but no single test for detection of H. pylori infection can be used as a fully reliable reference method. Therefore, concordant results of at least two biopsy-based tests (histology, culture, rapid urease test) are considered as the 'gold standard'. Most of the validation studies in children included only a few infants and toddlers, with low numbers particularly for H, pylori-infected individuals. Only when increasing numbers of patients were tested and separated into subgroups by age it became apparent that the accuracy of most tests is lower in young children if the same cut-off values are used as established for older childrenor adults. Therefore, statements such as 'a test has been validated with good results in children' must be interpreted with caution, unless differentage groups are considered with sufficient numbers of infected and non-infected children in each age group. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 12:52:56