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Titolo:
Polyamine metabolism revisited
Autore:
Urdiales, JL; Medina, MA; Sanchez-Jimenez, F;
Indirizzi:
Univ Malaga, Fac Sci, Dept Mol Biol & Biochem, E-29071 Malaga, Spain Univ Malaga Malaga Spain E-29071 l Biol & Biochem, E-29071 Malaga, Spain
Titolo Testata:
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
fascicolo: 9, volume: 13, anno: 2001,
pagine: 1015 - 1019
SICI:
0954-691X(200109)13:9<1015:PMR>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
S-ADENOSYLMETHIONINE DECARBOXYLASE; SPERMIDINE/SPERMINE N-1-ACETYLTRANSFERASE GENE; ORNITHINE DECARBOXYLASE; SPERMINE N1-ACETYLTRANSFERASE; MAMMALIAN-CELLS; MESSENGER-RNA; DEGRADATION; TRANSPORT; ARGININE; RAT;
Keywords:
ornithine decarboxylase; polyamine metabolism; S-adenosylmethionine decarboxylase; spermidine/spermine acetyltransferase;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Sanchez-Jimenez, F Univ Malaga, Fac Sci, Dept Mol Biol & Biochem, Campus Teatinos, E-29071 Malaga, Spain Univ Malaga Campus Teatinos Malaga Spain E-29071 Spain
Citazione:
J.L. Urdiales et al., "Polyamine metabolism revisited", EUR J GASTR, 13(9), 2001, pp. 1015-1019

Abstract

The natural polyamines putrescine, spermidine and spermine play an essential role in cell growth and differentiation, Cellular polyamine depletion results in inhibition of growth, whereas its accumulation appears to be toxic. Intracellular levels of polyamines are regulated by a multitude of mechanisms affecting their synthesis, degradation, uptake and excretion. The three key enzymes in the regulation of polyamine metabolism have short half-lives and are inducible. Ornithine and S-adenosylmethionine decarboxylases regulate polyamine biosynthesis whereas spermidine/spermine acetyltransferase regulates polyamine interconvertion and degradation. (C) 2001 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 17:47:34