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Titolo:
Renal loss of leptin in patients with nephrotic syndrome
Autore:
Schroth, M; Groschl, M; Dorr, HG; Blum, WF; Rascher, W; Dotsch, J;
Indirizzi:
Univ Erlangen Nurnberg, Klin & Poliklin Kinder & Jugendliche, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Erlangen Germany D-91054 -91054 Erlangen, Germany Lilly Deutschland GmbH, D-61350 Bad Homburg, Germany Lilly Deutschland GmbH Bad Homburg Germany D-61350 Bad Homburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF ENDOCRINOLOGY
fascicolo: 4, volume: 145, anno: 2001,
pagine: 463 - 468
SICI:
0804-4643(200110)145:4<463:RLOLIP>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
BODY-MASS INDEX; SERUM LEPTIN; PLASMA LEPTIN; OBESE GENE; SUPPRESSES LEPTIN; CHILDREN; ADOLESCENTS; EXPRESSION; WEIGHT; INSULIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Schroth, M Univ Erlangen Nurnberg, Klin & Poliklin Kinder & Jugendliche, Loschgestr 15, D-91054 Erlangen, Germany Univ Erlangen Nurnberg Loschgestr 15 Erlangen Germany D-91054
Citazione:
M. Schroth et al., "Renal loss of leptin in patients with nephrotic syndrome", EUR J ENDOC, 145(4), 2001, pp. 463-468

Abstract

Objective: In humans, short term changes of serum leptin lead to alterations in food intake and energy expenditure. The objective of the present study was to relate urine leptin concentrations with the extent of proteinuria in patients with nephrotic syndrome (NS). A second goal was to investigate the impact of potential urinary leptin losses on serum leptin concentrations and body composition. Design and Methods: Seventeen patients with proteinuria were compared withtwenty patients with remission of NS and ten healthy children. Leptin was measured by radioimmunoassay. Results: Urinary leptin excretion in proteinuric patients was significantly higher than in nonproteinuric patients with and without NS and in healthycontrols (2.64 +/-0.034 mug/g creatinine, 0.026 +/-0.05 mug/g creatinine, and 0.073 +/-0.11 mug/g creatinine respectively; P<0.001 and P<0.01 respectively compared with controls). Urine leptin positively correlated with urine IgG concentration (P=0.013, r(2) = 0.36) in the proteinuric group. No difference in serum leptin values could be demonstrated between the three groups. Conclusions: In summary, our data demonstrate a significant leptin excretion in children with severe proteinuria. Proteinuria, however, does not leadto changes in serum leptin, suggesting that the significant loss of leptinis compensated for by sustained up-regulation of leptin production.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 10:34:33