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Titolo:
Effects of regular ingestion of black tea on haemostasis and cell adhesionmolecules in humans
Autore:
Hodgson, JM; Puddey, IB; Mori, TA; Burke, V; Baker, RI; Beilin, LJ;
Indirizzi:
Univ Western Australia, Royal Perth Hosp, Dept Med, Perth, WA 6847, Australia Univ Western Australia Perth WA Australia 6847 Perth, WA 6847, Australia Royal Perth Hosp, HeartSearch, Perth, WA, Australia Royal Perth Hosp Perth WA Australia p, HeartSearch, Perth, WA, Australia Royal Perth Hosp, Dept Haematol, Perth, WA, Australia Royal Perth Hosp Perth WA Australia Dept Haematol, Perth, WA, Australia
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 10, volume: 55, anno: 2001,
pagine: 881 - 886
SICI:
0954-3007(200110)55:10<881:EORIOB>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
SOLUBLE P-SELECTIN; ACUTE MYOCARDIAL-INFARCTION; CORONARY HEART-DISEASE; APPARENTLY HEALTHY-MEN; ENDOTHELIAL-CELL; GREEN TEA; CAROTID ATHEROSCLEROSIS; FIBRINOLYTIC-ACTIVITY; PLATELET-AGGREGATION; CLOTTING FACTORS;
Keywords:
tea; polyphenols; platelets; cell adhesion molecules; soluble P-selectin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Hodgson, JM Univ Western Australia, Royal Perth Hosp, Dept Med, GPO Box X2213, Perth, WA 6847, Australia Univ Western Australia GPO Box X2213 Perth WA Australia 6847 a
Citazione:
J.M. Hodgson et al., "Effects of regular ingestion of black tea on haemostasis and cell adhesionmolecules in humans", EUR J CL N, 55(10), 2001, pp. 881-886

Abstract

Objective: To assess the effects in humans of regular ingestion of black tea on haemostasis-related variables and cell adhesion molecules. Design: Twenty-two subjects were recruited from the general population to a randomised-controlled crossover study. Subjects stopped drinking tea, apart from that provided, for the duration of the study. During a 4-week baseline period all subjects drank 5 cups/day (250 ml) of hot water. The effectsof 5 cups/day of black tea for 4 weeks were then compared with hot water. Platelet aggregation in response to three doses of collagen and ADP, plasmaconcentrations of coagulation and fibrinolytic factors (fibrinogen, factorVII, tPA, PAI-1) and plasma concentrations of cell adhesion molecules (soluble P-selectin, E-selectin, ICAM-1, VCAM-1) were assessed twice, one week apart, at the end of each period. Twenty-four hour urinary concentration of4-O-methylgallic acid (4OMGA), assessed once at the end of each period, was used as a marker of black tea polyphenol intake. Results: The 24 It urinary excretion of 4OMGA was increased during regularingestion of black tea in comparison to hot water (P<0.0001). Black tea resulted in lower soluble P-selectin (P= 0.01) in comparison to hot water, but did not influence other adhesion molecules. Soluble P-selectin was significantly correlated with mean collagen-stimulated platelet aggregation at baseline (r=0.61, P=0.003), and during regular ingestion of hot water (r=0.70, P<0.0001) and black tea (r=0.51, P=0.01). However, platelet aggregation was not different between the black tea and hot water periods for collagen- or ADP-stimulated aggregation at any dose. Coagulation and fibrinolytic factors were also not different between periods. Conclusions: The effect of black tea on soluble P-selectin provides a potential mechanism for cardiovascular benefits of regular ingestion of tea.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 01:01:10