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Titolo:
Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent historyof impaired glucose tolerance
Autore:
van Dijk, RAJM; Dekker, JM; Nijpels, G; Heine, RJ; Bouter, LM; Stehouwer, CDA;
Indirizzi:
Free Univ Amsterdam, Inst Cardiovasc Res, Amsterdam, Netherlands Free UnivAmsterdam Amsterdam Netherlands c Res, Amsterdam, Netherlands Free Univ Amsterdam Hosp, Dept Internal Med, Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands , Amsterdam, Netherlands Free Univ Amsterdam, Inst Res Extramural Med, Amsterdam, Netherlands Free Univ Amsterdam Amsterdam Netherlands l Med, Amsterdam, Netherlands Free Univ Amsterdam Hosp, Dept Endocrinol, Amsterdam, Netherlands Free Univ Amsterdam Hosp Amsterdam Netherlands , Amsterdam, Netherlands
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
fascicolo: 9, volume: 31, anno: 2001,
pagine: 756 - 763
SICI:
0014-2972(200109)31:9<756:BAPPAC>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
STAGE RENAL-DISEASE; CARDIOVASCULAR MORTALITY; ESSENTIAL-HYPERTENSION; MYOCARDIAL-INFARCTION; BLOOD-PRESSURE; ALL-CAUSE; DISTENSIBILITY; STIFFNESS; HOORN; RISK;
Keywords:
common carotid artery diameter; common carotid artery stiffness; impaired glucose tolerance; mortality pulse pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: van Dijk, RAJM Free Univ Amsterdam Hosp, Dept Radiol, POB 7057, NL-1007 MBAmsterdam, Netherlands Free Univ Amsterdam Hosp POB 7057 Amsterdam Netherlands NL-1007 MB
Citazione:
R.A.J.M. van Dijk et al., "Brachial artery pulse pressure and common carotid artery diameter: mutually independent associations with mortality in subjects with a recent historyof impaired glucose tolerance", EUR J CL IN, 31(9), 2001, pp. 756-763

Abstract

Background Decreased large artery function, as reflected by increased brachial artery pulse pressure and increased carotid artery diameter and stiffness, may contribute to the increased mortality risk that is observed in subjects with impaired glucose tolerance. We therefore investigated the association between brachial artery pulse pressure and carotid artery diameter and stiffness, which are estimates of central artery stiffness and arterial remodelling, respectively, and mortality in subjects with a recent history of impaired glucose tolerance. Design A prospective, population-based cohort study. We measured brachial artery pulse pressure by oscillometric blood pressure measurements, and common carotid artery diameter and distensibility and compliance coefficients by ultrasound in 140 subjects with a recent history of impaired glucose tolerance. During a median 6.6-year follow-up, 16 subjects died. Results Brachial artery pulse pressure and common carotid artery diameter were positively related to all-cause mortality [hazard ratios per standard deviation, 1.7 (1.2-2.5) and 2.1 (1.3-3.3), respectively], Results were similar after adjustment for gender, age, waist-to-hip ratio, body mass index,total cholesterol concentration, pre-existent cardiovascular disease, and hypertension, I and after additional mutual adjustment. Common carotid artery distensibility and compliance coefficients were not statistically significantly associated with mortality. Conclusions Among subjects with a recent history of impaired glucose tolerance, brachial artery pulse pressure and common carotid artery diameter areindependently associated with mortality risk. Stiffness of the central arteries may explain the association between pulse pressure and mortality risk. The association between carotid diameter and mortality risk is more likely to reflect arterial remodelling in response to atherosclerosis than that in response to increased local stiffness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:42:25